ID   A0QQ04_MYCS2            Unreviewed;       448 AA.
AC   A0QQ04;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   SubName: Full=4-aminobutyrate transaminase {ECO:0000313|EMBL:ABK69652.1};
DE            EC=2.6.1.19 {ECO:0000313|EMBL:ABK69652.1};
GN   Name=gabT {ECO:0000313|EMBL:ABK69652.1};
GN   OrderedLocusNames=MSMEG_0581 {ECO:0000313|EMBL:ABK69652.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK69652.1, ECO:0000313|Proteomes:UP000000757};
RN   [1] {ECO:0000313|EMBL:ABK69652.1, ECO:0000313|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:3Q8N}
RP   X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 2-448.
RX   PubMed=25613812; DOI=10.1016/j.tube.2014.12.003;
RA   Baugh L., Phan I., Begley D.W., Clifton M.C., Armour B., Dranow D.M.,
RA   Taylor B.M., Muruthi M.M., Abendroth J., Fairman J.W., Fox D.,
RA   Dieterich S.H., Staker B.L., Gardberg A.S., Choi R., Hewitt S.N.,
RA   Napuli A.J., Myers J., Barrett L.K., Zhang Y., Ferrell M., Mundt E.,
RA   Thompkins K., Tran N., Lyons-Abbott S., Abramov A., Sekar A.,
RA   Serbzhinskiy D., Lorimer D., Buchko G.W., Stacy R., Stewart L.J.,
RA   Edwards T.E., Van Voorhis W.C., Myler P.J.;
RT   "Increasing the structural coverage of tuberculosis drug targets.";
RL   Tuberculosis 95:142-148(2015).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00008954,
CC       ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; CP000480; ABK69652.1; -; Genomic_DNA.
DR   RefSeq; WP_003892002.1; NZ_SIJM01000009.1.
DR   RefSeq; YP_884992.1; NC_008596.1.
DR   PDB; 3Q8N; X-ray; 2.05 A; A/B/C/D=2-448.
DR   PDBsum; 3Q8N; -.
DR   AlphaFoldDB; A0QQ04; -.
DR   SMR; A0QQ04; -.
DR   STRING; 246196.MSMEG_0581; -.
DR   PaxDb; 246196-MSMEI_0566; -.
DR   GeneID; 66738760; -.
DR   KEGG; msm:MSMEG_0581; -.
DR   PATRIC; fig|246196.19.peg.578; -.
DR   eggNOG; COG0160; Bacteria.
DR   OrthoDB; 9801052at2; -.
DR   EvolutionaryTrace; A0QQ04; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009448; P:gamma-aminobutyric acid metabolic process; IEA:InterPro.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004632; 4NH2But_aminotransferase_bac.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR049704; Aminotrans_3_PPA_site.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR00700; GABAtrnsam; 1.
DR   PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR   PANTHER; PTHR11986:SF58; LEUCINE_METHIONINE RACEMASE; 1.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3Q8N};
KW   Aminotransferase {ECO:0000313|EMBL:ABK69652.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU003560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW   Transferase {ECO:0000313|EMBL:ABK69652.1}.
SQ   SEQUENCE   448 AA;  46490 MW;  2F846454C81E6B7F CRC64;
     MTIAEIAGRT LTQERRLVTA IPGPISQELQ ARKQSAVAAG VGVTLPVYVV AAGGGVLADA
     DGNQLIDFGS GIAVTTVGNS APAVVDAVTQ QVAAFTHTCF MVTPYEGYVK VAEHLNRLTP
     GDHEKRTALF NSGAEAVENA VKIARAYTRR QAVVVFDHAY HGRTNLTMAM TAKNQPYKHG
     FGPFANEVYR VPTSYPFRDG ETDGAAAAAH ALDLINKQVG ADNVAAVVIE PVHGEGGFVV
     PAPGFLGALQ KWCTDNGAVF VADEVQTGFA RTGALFACEH ENVVPDLIVT AKGIAGGLPL
     SAVTGRAEIM DGPQSGGLGG TYGGNPLACA AALAVIDTIE RENLVARARA IGETMLSRLG
     ALAAADPRIG EVRGRGAMIA VELVKPGTTE PDADLTKRVA AAAHAQGLVV LTCGTYGNVL
     RFLPPLSMPD HLLDEGLDIL AAVFAEVK
//