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Protein
Submitted name:

4-aminobutyrate aminotransferase

Gene

gabT

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseImported, Transferase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-581-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
4-aminobutyrate aminotransferaseImported (EC:2.6.1.19Imported)
Submitted name:
4-aminobutyrate transaminaseImported (EC:2.6.1.19Imported)
Gene namesi
Name:gabTImported
Ordered Locus Names:MSMEG_0581Imported, MSMEI_0566Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006158 Componenti: Chromosome UP000000757 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0581.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q8NX-ray2.05A/B/C/D2-448[»]
ProteinModelPortaliA0QQ04.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0QQ04.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK07250.
OMAiPEGNHYL.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QQ04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAEIAGRT LTQERRLVTA IPGPISQELQ ARKQSAVAAG VGVTLPVYVV
60 70 80 90 100
AAGGGVLADA DGNQLIDFGS GIAVTTVGNS APAVVDAVTQ QVAAFTHTCF
110 120 130 140 150
MVTPYEGYVK VAEHLNRLTP GDHEKRTALF NSGAEAVENA VKIARAYTRR
160 170 180 190 200
QAVVVFDHAY HGRTNLTMAM TAKNQPYKHG FGPFANEVYR VPTSYPFRDG
210 220 230 240 250
ETDGAAAAAH ALDLINKQVG ADNVAAVVIE PVHGEGGFVV PAPGFLGALQ
260 270 280 290 300
KWCTDNGAVF VADEVQTGFA RTGALFACEH ENVVPDLIVT AKGIAGGLPL
310 320 330 340 350
SAVTGRAEIM DGPQSGGLGG TYGGNPLACA AALAVIDTIE RENLVARARA
360 370 380 390 400
IGETMLSRLG ALAAADPRIG EVRGRGAMIA VELVKPGTTE PDADLTKRVA
410 420 430 440
AAAHAQGLVV LTCGTYGNVL RFLPPLSMPD HLLDEGLDIL AAVFAEVK
Length:448
Mass (Da):46,490
Last modified:January 9, 2007 - v1
Checksum:i2F846454C81E6B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69652.1.
CP001663 Genomic DNA. Translation: AFP37047.1.
RefSeqiYP_006565342.1. NC_018289.1.
YP_884992.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK69652; ABK69652; MSMEG_0581.
AFP37047; AFP37047; MSMEI_0566.
GeneIDi4536614.
KEGGimsm:MSMEG_0581.
PATRICi18073632. VBIMycSme59918_0578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK69652.1.
CP001663 Genomic DNA. Translation: AFP37047.1.
RefSeqiYP_006565342.1. NC_018289.1.
YP_884992.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q8NX-ray2.05A/B/C/D2-448[»]
ProteinModelPortaliA0QQ04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_0581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK69652; ABK69652; MSMEG_0581.
AFP37047; AFP37047; MSMEI_0566.
GeneIDi4536614.
KEGGimsm:MSMEG_0581.
PATRICi18073632. VBIMycSme59918_0578.

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK07250.
OMAiPEGNHYL.
OrthoDBiEOG6QVRHN.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-581-MONOMER.

Miscellaneous databases

EvolutionaryTraceiA0QQ04.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.
  5. "Crystal structure of 4-aminobutyrate transaminase from Mycobacterium smegmatis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Gardberg A., Edwards T., Staker B., Stewart L.
    Submitted (DEC-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 2-448.

Entry informationi

Entry nameiA0QQ04_MYCS2
AccessioniPrimary (citable) accession number: A0QQ04
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.