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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei154NADPUniRule annotation1
Binding sitei184SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei222SubstrateUniRule annotation1
Binding sitei241SubstrateUniRule annotation1
Active sitei246Proton acceptorUniRule annotation1
Binding sitei345SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi94 – 95NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:MSMEG_0314, MSMEI_0307
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003968121 – 495Glucose-6-phosphate 1-dehydrogenaseAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki51Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiA0QP90

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0314

Structurei

3D structure databases

ProteinModelPortaliA0QP90
SMRiA0QP90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W Bacteria
COG0364 LUCA
HOGENOMiHOG000046191
KOiK00036
OMAiCDMLVFG
OrthoDBiPOG091H04ZM

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0QP90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRTPSPVDP CDFVIFGGTG DLAARKLLPA LYLRDRDGQL AGATRIIGVA
60 70 80 90 100
KAGLDDAGYR NTVRAGLARH VEPDLLDSDV VDRFLSRLRF VSVDLTEPSD
110 120 130 140 150
YAAVGDVLTS PDGGSGHDIR VFYLACAPAL FGPICGALGA QGLVTESSRV
160 170 180 190 200
VLEKPIGRDL ASAQQINEAV GAVFAEHQIF RIDHYLGKES VQQLLVTRFG
210 220 230 240 250
NTWLEPLWNS SRIDHVQITA AESLGVGARG DYYDQSGALR DMLQNHLLQV
260 270 280 290 300
LCLVAMEPPT HVNRESVRDE KRKVLEALEP LTAEQTQRDT VTGQYGPGLV
310 320 330 340 350
GDEVVGSYRE EVADPHSRTE TFVAVKAHIR NWRWAGVPFY LRTGKRMSQR
360 370 380 390 400
FSEIVVQFKP VPLPMFPGIE GTSEPNRLII SLQPDEAIRL EMTAKEPGSG
410 420 430 440 450
GRLRPVSLAL NYTEAFPERS PDAYERLLMD VVRGDPTLFM RRDEVEAAWA
460 470 480 490
WAEPILRHWQ DADRVPRTYP AGTDGPVDAA TLIERDGRRW HGGAA
Length:495
Mass (Da):54,622
Last modified:January 9, 2007 - v1
Checksum:iD3CAEE679F671727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72464.1
CP001663 Genomic DNA Translation: AFP36788.1
RefSeqiWP_011726838.1, NZ_CP009494.1
YP_884728.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK72464; ABK72464; MSMEG_0314
AFP36788; AFP36788; MSMEI_0307
GeneIDi4537542
KEGGimsb:LJ00_01575
msg:MSMEI_0307
msm:MSMEG_0314
PATRICifig|246196.19.peg.311

Similar proteinsi

Entry informationi

Entry nameiG6PD_MYCS2
AccessioniPrimary (citable) accession number: A0QP90
Secondary accession number(s): I7FCZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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