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A0QP90

- G6PD_MYCS2

UniProt

A0QP90 - G6PD_MYCS2

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei154 – 1541NADPUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei188 – 1881SubstrateUniRule annotation
    Binding sitei222 – 2221SubstrateUniRule annotation
    Binding sitei241 – 2411SubstrateUniRule annotation
    Active sitei246 – 2461Proton acceptorUniRule annotation
    Binding sitei345 – 3451SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi94 – 952NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-314-MONOMER.
    RETL1328306-WGS:GSTH-717-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:MSMEG_0314, MSMEI_0307
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Glucose-6-phosphate 1-dehydrogenasePRO_0000396812Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki51 – 51Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_0314.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QP90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiWNAAHID.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QP90-1 [UniParc]FASTAAdd to Basket

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    MNRTPSPVDP CDFVIFGGTG DLAARKLLPA LYLRDRDGQL AGATRIIGVA    50
    KAGLDDAGYR NTVRAGLARH VEPDLLDSDV VDRFLSRLRF VSVDLTEPSD 100
    YAAVGDVLTS PDGGSGHDIR VFYLACAPAL FGPICGALGA QGLVTESSRV 150
    VLEKPIGRDL ASAQQINEAV GAVFAEHQIF RIDHYLGKES VQQLLVTRFG 200
    NTWLEPLWNS SRIDHVQITA AESLGVGARG DYYDQSGALR DMLQNHLLQV 250
    LCLVAMEPPT HVNRESVRDE KRKVLEALEP LTAEQTQRDT VTGQYGPGLV 300
    GDEVVGSYRE EVADPHSRTE TFVAVKAHIR NWRWAGVPFY LRTGKRMSQR 350
    FSEIVVQFKP VPLPMFPGIE GTSEPNRLII SLQPDEAIRL EMTAKEPGSG 400
    GRLRPVSLAL NYTEAFPERS PDAYERLLMD VVRGDPTLFM RRDEVEAAWA 450
    WAEPILRHWQ DADRVPRTYP AGTDGPVDAA TLIERDGRRW HGGAA 495
    Length:495
    Mass (Da):54,622
    Last modified:January 9, 2007 - v1
    Checksum:iD3CAEE679F671727
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK72464.1.
    CP001663 Genomic DNA. Translation: AFP36788.1.
    RefSeqiYP_006565083.1. NC_018289.1.
    YP_884728.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK72464; ABK72464; MSMEG_0314.
    AFP36788; AFP36788; MSMEI_0307.
    GeneIDi4537542.
    KEGGimsg:MSMEI_0307.
    msm:MSMEG_0314.
    PATRICi18073098. VBIMycSme59918_0311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK72464.1 .
    CP001663 Genomic DNA. Translation: AFP36788.1 .
    RefSeqi YP_006565083.1. NC_018289.1.
    YP_884728.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0QP90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_0314.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK72464 ; ABK72464 ; MSMEG_0314 .
    AFP36788 ; AFP36788 ; MSMEI_0307 .
    GeneIDi 4537542.
    KEGGi msg:MSMEI_0307.
    msm:MSMEG_0314.
    PATRICi 18073098. VBIMycSme59918_0311.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi WNAAHID.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci MSME246196:GJ4Y-314-MONOMER.
    RETL1328306-WGS:GSTH-717-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. Cited for: PUPYLATION AT LYS-51, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiG6PD_MYCS2
    AccessioniPrimary (citable) accession number: A0QP90
    Secondary accession number(s): I7FCZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3