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Protein

FHA domain-containing protein FhaB

Gene

fhaB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress.1 Publication

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-34-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FHA domain-containing protein FhaB
Alternative name(s):
FtsZ-interacting protein A
Gene namesi
Name:fhaB
Synonyms:fipA
Ordered Locus Names:MSMEG_0034, MSMEI_0036
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants show increased susceptibility to oxidative stress and elongation of cells due to a defect in septum formation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155FHA domain-containing protein FhaBPRO_0000419672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771Phosphothreonine; by PknABy similarity

Post-translational modificationi

Phosphorylated by PknA. Dephosphorylated by PstP.1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with FtsZ.1 Publication

Protein-protein interaction databases

STRINGi246196.MSMEG_0034.

Structurei

3D structure databases

ProteinModelPortaliA0QNG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13250FHAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105HZM. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000235793.
OMAiGQWIVED.
OrthoDBiEOG6WHNMG.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR032030. YscD_cytoplasmic_dom.
[Graphical view]
PfamiPF16697. Yop-YscD_cpl. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QNG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGLVLQLTR VGFLLLLWLF IWSVLRILRT DIYAPTGAVM VRRGLALRGS
60 70 80 90 100
LLPNRQRRHV ARQLVVTEGA LAGTRITLGN QPVLIGRADD STLVLTDDYA
110 120 130 140 150
STRHARLSPR GSEWYVEDLG STNGTYLDRA KVTTAVKVPI GAPVRIGKTV

IELRP
Length:155
Mass (Da):17,125
Last modified:January 9, 2007 - v1
Checksum:iC5994E935EDD1917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74891.1.
CP001663 Genomic DNA. Translation: AFP36519.1.
RefSeqiWP_011726620.1. NZ_CP009494.1.
YP_884454.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74891; ABK74891; MSMEG_0034.
AFP36519; AFP36519; MSMEI_0036.
GeneIDi4531676.
KEGGimsb:LJ00_00170.
msg:MSMEI_0036.
msm:MSMEG_0034.
PATRICi18072536. VBIMycSme59918_0032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74891.1.
CP001663 Genomic DNA. Translation: AFP36519.1.
RefSeqiWP_011726620.1. NZ_CP009494.1.
YP_884454.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QNG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_0034.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74891; ABK74891; MSMEG_0034.
AFP36519; AFP36519; MSMEI_0036.
GeneIDi4531676.
KEGGimsb:LJ00_00170.
msg:MSMEI_0036.
msm:MSMEG_0034.
PATRICi18072536. VBIMycSme59918_0032.

Phylogenomic databases

eggNOGiENOG4105HZM. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000235793.
OMAiGQWIVED.
OrthoDBiEOG6WHNMG.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-34-MONOMER.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR032030. YscD_cytoplasmic_dom.
[Graphical view]
PfamiPF16697. Yop-YscD_cpl. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. "Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division."
    Sureka K., Hossain T., Mukherjee P., Chatterjee P., Datta P., Kundu M., Basu J.
    PLoS ONE 5:E8590-E8590(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FTSZ, PHOSPHORYLATION, DEPHOSPHORYLATION, DISRUPTION PHENOTYPE.
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiFHAB_MYCS2
AccessioniPrimary (citable) accession number: A0QNG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.