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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecF
Gene namesi
Name:recF
Ordered Locus Names:MSMEG_0003, MSMEI_0005
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002936011 – 384DNA replication and repair protein RecFAdd BLAST384

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0003.

Structurei

3D structure databases

ProteinModelPortaliA0QND8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.Curated

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiPOG091H00U7.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00365. RecF. 1 hit.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QND8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARHLGLTD FRSWARVDLD LEPGRTVFVG PNGFGKTNLV EALWYSATLG
60 70 80 90 100
SHRVATDAPL IRAGAERAIV STIVVNEGRE LAVDLEITSG RANKARLNRS
110 120 130 140 150
PVRSAREILG VLRAVLFSPE DLSLVRGDPG DRRRYLDELA TTRRPALAGV
160 170 180 190 200
RADYDKVVRQ RTALLKTAAG ARYRGDRSVI DTLEVWDGHL AAHGAALVAS
210 220 230 240 250
RVKLVEELQP EVEKAYQLLA PASRPAAIRY RSSVEAIEDA PGPESVEFYE
260 270 280 290 300
AALLDALARR RDAELERGVC LVGPHRDDLE LRLGDQPAKG FASHGESWSM
310 320 330 340 350
ALALRLGAYE LLCSDGVEPV LLLDDVFAEL DTSRRRALAT VAGSAEQVLV
360 370 380
TAAVGEDIPE DWDARRVEIR MVEDDGGRVS MVAS
Length:384
Mass (Da):41,920
Last modified:January 9, 2007 - v1
Checksum:i1F2045B42BA73262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK70100.1.
CP001663 Genomic DNA. Translation: AFP36490.1.
X94224 Genomic DNA. Translation: CAA63915.1.
RefSeqiWP_011726603.1. NC_018289.1.
YP_884426.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70100; ABK70100; MSMEG_0003.
AFP36490; AFP36490; MSMEI_0005.
GeneIDi4532650.
KEGGimsg:MSMEI_0005.
msm:MSMEG_0003.
PATRICi18072474. VBIMycSme59918_0003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK70100.1.
CP001663 Genomic DNA. Translation: AFP36490.1.
X94224 Genomic DNA. Translation: CAA63915.1.
RefSeqiWP_011726603.1. NC_018289.1.
YP_884426.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0QND8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_0003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK70100; ABK70100; MSMEG_0003.
AFP36490; AFP36490; MSMEI_0005.
GeneIDi4532650.
KEGGimsg:MSMEI_0005.
msm:MSMEG_0003.
PATRICi18072474. VBIMycSme59918_0003.

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiPOG091H00U7.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00365. RecF. 1 hit.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRECF_MYCS2
AccessioniPrimary (citable) accession number: A0QND8
Secondary accession number(s): I7F4B6, P50916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.