Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot A0QMB9 (GABD1_MYCA1)

Last modified June 16, 2009. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Succinate-semialdehyde dehydrogenase [NADP+]
      Short name=SSADH
      Short name=SSDH
    EC=1.2.1.16
Gene names
Name: gabD1
Ordered Locus Names: MAV_4936
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Hide | Top

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.

Catalytic activity

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Hide | Top

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinate-semialdehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Succinate-semialdehyde dehydrogenase [NADP+]
PRO_0000310700

Regions

Nucleotide binding210 – 2156NAD or NADP By similarity

Sites

Active site2321 By similarity
Active site2661 By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
A0QMB9-1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 39C4E3CBCDD495C5

FASTA47250,010
        10         20         30         40         50         60 
MPIATINPAT GETVKTFTPA SDAEVDAAIA RAYERFLDYR HSTTFAQRAQ WANATADLLE 

        70         80         90        100        110        120 
AEADEVAAMM TLEMGKTLKS AKAEALKCAK GFRYYAQNAE QLLADEPADA GKVGAARAYI 

       130        140        150        160        170        180 
RYQPLGVVLA VMPWNFPLWQ AVRFAAPALM AGNVGILKHA SNVPQSALYL ADVITRGGFP 

       190        200        210        220        230        240 
EGCFQTLLVP SSAVERILRD PRVAAATLTG SEPAGQSVAA IAGDEIKPTV LELGGSDPFI 

       250        260        270        280        290        300 
VMPSADLDEA VKTAVTARVQ NNGQSCIAAK RFIVHTDIYD TFVDKFVEQM KALKVGDPTD 

       310        320        330        340        350        360 
PATDVGPLAT ESGRDEIAKQ VDDAVAAGAT LRCGGKPLDG PGWFYPPTVV TDITKDMALY 

       370        380        390        400        410        420 
TEEVFGPVAS MYRAADIDEA IEIANATTFG LGSNAWTNDA AEQQRFIDDI EAGQVFINGM 

       430        440        450        460        470 
TVSYPELGFG GVKRSGYGRE LAGLGIRAFC NAKTVWIGSS KSGDAGGGSK VE

« Hide

Hide | Top

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

CP000479 Genomic DNA. Translation: ABK64449.1.
RefSeqYP_884057.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4526409.
GenomeReviewsGene locus MAV_4936 in contig CP000479_GR.
KEGGmav:MAV_4936.
TIGRMAV_4936.

Phylogenomic databases

OMAA0QMB9. VPQSALY.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameGABD1_MYCA1
AccessionPrimary (citable) accession number: A0QMB9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents