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A0QMB9 (GABD1_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinate-semialdehyde dehydrogenase [NADP+]
Short name=SSADH
Short name=SSDH
EC=1.2.1.79
Gene names
Name:gabD1
Ordered Locus Names:MAV_4936
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Succinate-semialdehyde dehydrogenase [NADP+]
PRO_0000310700

Regions

Nucleotide binding134 – 1352NADP By similarity
Nucleotide binding158 – 1614NADP By similarity
Nucleotide binding210 – 2112NADP By similarity

Sites

Active site2321Proton acceptor By similarity
Active site2661Nucleophile By similarity
Binding site2331NADP; via carbonyl oxygen By similarity
Binding site3631NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QMB9 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 39C4E3CBCDD495C5

FASTA47250,010
        10         20         30         40         50         60 
MPIATINPAT GETVKTFTPA SDAEVDAAIA RAYERFLDYR HSTTFAQRAQ WANATADLLE 

        70         80         90        100        110        120 
AEADEVAAMM TLEMGKTLKS AKAEALKCAK GFRYYAQNAE QLLADEPADA GKVGAARAYI 

       130        140        150        160        170        180 
RYQPLGVVLA VMPWNFPLWQ AVRFAAPALM AGNVGILKHA SNVPQSALYL ADVITRGGFP 

       190        200        210        220        230        240 
EGCFQTLLVP SSAVERILRD PRVAAATLTG SEPAGQSVAA IAGDEIKPTV LELGGSDPFI 

       250        260        270        280        290        300 
VMPSADLDEA VKTAVTARVQ NNGQSCIAAK RFIVHTDIYD TFVDKFVEQM KALKVGDPTD 

       310        320        330        340        350        360 
PATDVGPLAT ESGRDEIAKQ VDDAVAAGAT LRCGGKPLDG PGWFYPPTVV TDITKDMALY 

       370        380        390        400        410        420 
TEEVFGPVAS MYRAADIDEA IEIANATTFG LGSNAWTNDA AEQQRFIDDI EAGQVFINGM 

       430        440        450        460        470 
TVSYPELGFG GVKRSGYGRE LAGLGIRAFC NAKTVWIGSS KSGDAGGGSK VE

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK64449.1.
RefSeqYP_884057.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QMB9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QMB9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000011144; EBMYCP00000011030; EBMYCG00000011142.
GeneID4526409.
GenomeReviewsGene locus MAV_4936 in contig CP000479_GR.
KEGGmav:MAV_4936.
PATRIC17991564. VBIMycAvi38287_4849.
TIGRMAV_4936.

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00050000015659.
HOGENOMHBG752218.
OMAVPQSALY.
PhylomeDBA0QMB9.
ProtClustDBPRK09406.

Enzyme and pathway databases

BioCycMAVI243243:MAV_4936-MONOMER.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD1_MYCA1
AccessionPrimary (citable) accession number: A0QMB9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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