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A0QLL2

- DEOC_MYCA1

UniProt

A0QLL2 - DEOC_MYCA1

Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

    Catalytic activityi

    2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei158 – 1581Schiff-base intermediate with acetaldehydeUniRule annotation
    Active sitei188 – 1881UniRule annotation

    GO - Molecular functioni

    1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate catabolic process Source: UniProtKB-HAMAP
    2. deoxyribonucleotide catabolic process Source: InterPro
    3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciMAVI243243:GH3Y-4672-MONOMER.
    UniPathwayiUPA00002; UER00468.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
    Short name:
    DERAUniRule annotation
    Alternative name(s):
    2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
    PhosphodeoxyriboaldolaseUniRule annotation
    Short name:
    DeoxyriboaldolaseUniRule annotation
    Gene namesi
    Name:deoCUniRule annotation
    Ordered Locus Names:MAV_4672
    OrganismiMycobacterium avium (strain 104)
    Taxonomic identifieri243243 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000001574: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Deoxyribose-phosphate aldolasePRO_1000015324Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243243.MAV_4672.

    Structurei

    Secondary structure

    1
    223
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 95
    Beta strandi12 – 154
    Helixi23 – 3614
    Beta strandi39 – 435
    Helixi45 – 473
    Helixi48 – 536
    Beta strandi60 – 656
    Turni66 – 683
    Helixi73 – 8513
    Beta strandi89 – 946
    Helixi97 – 1015
    Helixi105 – 11915
    Beta strandi122 – 1276
    Helixi130 – 1367
    Helixi139 – 15113
    Beta strandi155 – 1584
    Helixi171 – 18111
    Beta strandi184 – 1929
    Helixi196 – 2049
    Beta strandi208 – 2147
    Helixi215 – 2206

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NG3X-ray2.15A/B/C/D1-223[»]
    ProteinModelPortaliA0QLL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA0QLL2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0274.
    HOGENOMiHOG000241645.
    KOiK01619.
    OMAiRLAETIM.
    OrthoDBiEOG6QZMW5.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00114. DeoC_type1.
    InterProiIPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    IPR028581. DeoC_typeI.
    [Graphical view]
    PANTHERiPTHR10889. PTHR10889. 1 hit.
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001357. DeoC. 1 hit.
    TIGRFAMsiTIGR00126. deoC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0QLL2-1 [UniParc]FASTAAdd to Basket

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    MTPTRAQLAA FVDHTLLKPE ATAADVAALV TEAAELGVYA VCVSPPMVPA    50
    AVQAGAGVRV ASVAGFPSGK HVSAVKAHEA ALAVASGAAE IDMVIDVGAA 100
    LAGDLDGVRA DIAAVRGAVG GAVLKVIVES SALLALADEH TLVRVCRAAE 150
    DAGADFVKTS TGFHPSGGAS VRAVALMAEA VGGRLGVKAS GGIRTAADAL 200
    AMLDAGATRL GLSGTRAVLD GLG 223
    Length:223
    Mass (Da):21,723
    Last modified:January 9, 2007 - v1
    Checksum:i33A436559EB7FC1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK67136.1.
    RefSeqiYP_883800.1. NC_008595.1.

    Genome annotation databases

    EnsemblBacteriaiABK67136; ABK67136; MAV_4672.
    GeneIDi4528214.
    KEGGimav:MAV_4672.
    PATRICi17991042. VBIMycAvi38287_4590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK67136.1 .
    RefSeqi YP_883800.1. NC_008595.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NG3 X-ray 2.15 A/B/C/D 1-223 [» ]
    ProteinModelPortali A0QLL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243243.MAV_4672.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK67136 ; ABK67136 ; MAV_4672 .
    GeneIDi 4528214.
    KEGGi mav:MAV_4672.
    PATRICi 17991042. VBIMycAvi38287_4590.

    Phylogenomic databases

    eggNOGi COG0274.
    HOGENOMi HOG000241645.
    KOi K01619.
    OMAi RLAETIM.
    OrthoDBi EOG6QZMW5.

    Enzyme and pathway databases

    UniPathwayi UPA00002 ; UER00468 .
    BioCyci MAVI243243:GH3Y-4672-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei A0QLL2.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00114. DeoC_type1.
    InterProi IPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    IPR028581. DeoC_typeI.
    [Graphical view ]
    PANTHERi PTHR10889. PTHR10889. 1 hit.
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001357. DeoC. 1 hit.
    TIGRFAMsi TIGR00126. deoC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 104.

    Entry informationi

    Entry nameiDEOC_MYCA1
    AccessioniPrimary (citable) accession number: A0QLL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3