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A0QLL2

- DEOC_MYCA1

UniProt

A0QLL2 - DEOC_MYCA1

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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581Schiff-base intermediate with acetaldehydeUniRule annotation
Active sitei188 – 1881UniRule annotation

GO - Molecular functioni

  1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate catabolic process Source: UniProtKB-HAMAP
  2. deoxyribonucleotide catabolic process Source: InterPro
  3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-4672-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:MAV_4672
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Deoxyribose-phosphate aldolasePRO_1000015324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_4672.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 95Combined sources
Beta strandi12 – 154Combined sources
Helixi23 – 3614Combined sources
Beta strandi39 – 435Combined sources
Helixi45 – 473Combined sources
Helixi48 – 536Combined sources
Beta strandi60 – 656Combined sources
Turni66 – 683Combined sources
Helixi73 – 8513Combined sources
Beta strandi89 – 946Combined sources
Helixi97 – 1015Combined sources
Helixi105 – 11915Combined sources
Beta strandi122 – 1276Combined sources
Helixi130 – 1367Combined sources
Helixi139 – 15113Combined sources
Beta strandi155 – 1584Combined sources
Helixi171 – 18111Combined sources
Beta strandi184 – 1929Combined sources
Helixi196 – 2049Combined sources
Beta strandi208 – 2147Combined sources
Helixi215 – 2206Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NG3X-ray2.15A/B/C/D1-223[»]
ProteinModelPortaliA0QLL2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0QLL2.

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiRLAETIM.
OrthoDBiEOG6QZMW5.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QLL2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPTRAQLAA FVDHTLLKPE ATAADVAALV TEAAELGVYA VCVSPPMVPA
60 70 80 90 100
AVQAGAGVRV ASVAGFPSGK HVSAVKAHEA ALAVASGAAE IDMVIDVGAA
110 120 130 140 150
LAGDLDGVRA DIAAVRGAVG GAVLKVIVES SALLALADEH TLVRVCRAAE
160 170 180 190 200
DAGADFVKTS TGFHPSGGAS VRAVALMAEA VGGRLGVKAS GGIRTAADAL
210 220
AMLDAGATRL GLSGTRAVLD GLG
Length:223
Mass (Da):21,723
Last modified:January 9, 2007 - v1
Checksum:i33A436559EB7FC1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK67136.1.
RefSeqiWP_011726185.1. NC_008595.1.
YP_883800.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK67136; ABK67136; MAV_4672.
GeneIDi4528214.
KEGGimav:MAV_4672.
PATRICi17991042. VBIMycAvi38287_4590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK67136.1 .
RefSeqi WP_011726185.1. NC_008595.1.
YP_883800.1. NC_008595.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NG3 X-ray 2.15 A/B/C/D 1-223 [» ]
ProteinModelPortali A0QLL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243243.MAV_4672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK67136 ; ABK67136 ; MAV_4672 .
GeneIDi 4528214.
KEGGi mav:MAV_4672.
PATRICi 17991042. VBIMycAvi38287_4590.

Phylogenomic databases

eggNOGi COG0274.
HOGENOMi HOG000241645.
KOi K01619.
OMAi RLAETIM.
OrthoDBi EOG6QZMW5.

Enzyme and pathway databases

UniPathwayi UPA00002 ; UER00468 .
BioCyci MAVI243243:GH3Y-4672-MONOMER.

Miscellaneous databases

EvolutionaryTracei A0QLL2.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00114. DeoC_type1.
InterProi IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view ]
PANTHERi PTHR10889. PTHR10889. 1 hit.
Pfami PF01791. DeoC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001357. DeoC. 1 hit.
TIGRFAMsi TIGR00126. deoC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiDEOC_MYCA1
AccessioniPrimary (citable) accession number: A0QLL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3