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A0QLL2

- DEOC_MYCA1

UniProt

A0QLL2 - DEOC_MYCA1

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Protein
Deoxyribose-phosphate aldolase
Gene
deoC, MAV_4672
Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581Schiff-base intermediate with acetaldehyde By similarity
Active sitei188 – 1881 By similarity

GO - Molecular functioni

  1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate catabolic process Source: UniProtKB-HAMAP
  2. deoxyribonucleotide catabolic process Source: InterPro
  3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-4672-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:deoC
Ordered Locus Names:MAV_4672
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Deoxyribose-phosphate aldolaseUniRule annotation
PRO_1000015324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_4672.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 95
Beta strandi12 – 154
Helixi23 – 3614
Beta strandi39 – 435
Helixi45 – 473
Helixi48 – 536
Beta strandi60 – 656
Turni66 – 683
Helixi73 – 8513
Beta strandi89 – 946
Helixi97 – 1015
Helixi105 – 11915
Beta strandi122 – 1276
Helixi130 – 1367
Helixi139 – 15113
Beta strandi155 – 1584
Helixi171 – 18111
Beta strandi184 – 1929
Helixi196 – 2049
Beta strandi208 – 2147
Helixi215 – 2206

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NG3X-ray2.15A/B/C/D1-223[»]
ProteinModelPortaliA0QLL2.

Miscellaneous databases

EvolutionaryTraceiA0QLL2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiRLAETIM.
OrthoDBiEOG6QZMW5.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QLL2-1 [UniParc]FASTAAdd to Basket

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MTPTRAQLAA FVDHTLLKPE ATAADVAALV TEAAELGVYA VCVSPPMVPA    50
AVQAGAGVRV ASVAGFPSGK HVSAVKAHEA ALAVASGAAE IDMVIDVGAA 100
LAGDLDGVRA DIAAVRGAVG GAVLKVIVES SALLALADEH TLVRVCRAAE 150
DAGADFVKTS TGFHPSGGAS VRAVALMAEA VGGRLGVKAS GGIRTAADAL 200
AMLDAGATRL GLSGTRAVLD GLG 223
Length:223
Mass (Da):21,723
Last modified:January 9, 2007 - v1
Checksum:i33A436559EB7FC1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK67136.1.
RefSeqiYP_883800.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK67136; ABK67136; MAV_4672.
GeneIDi4528214.
KEGGimav:MAV_4672.
PATRICi17991042. VBIMycAvi38287_4590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK67136.1 .
RefSeqi YP_883800.1. NC_008595.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NG3 X-ray 2.15 A/B/C/D 1-223 [» ]
ProteinModelPortali A0QLL2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243243.MAV_4672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK67136 ; ABK67136 ; MAV_4672 .
GeneIDi 4528214.
KEGGi mav:MAV_4672.
PATRICi 17991042. VBIMycAvi38287_4590.

Phylogenomic databases

eggNOGi COG0274.
HOGENOMi HOG000241645.
KOi K01619.
OMAi RLAETIM.
OrthoDBi EOG6QZMW5.

Enzyme and pathway databases

UniPathwayi UPA00002 ; UER00468 .
BioCyci MAVI243243:GH3Y-4672-MONOMER.

Miscellaneous databases

EvolutionaryTracei A0QLL2.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00114. DeoC_type1.
InterProi IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view ]
PANTHERi PTHR10889. PTHR10889. 1 hit.
Pfami PF01791. DeoC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001357. DeoC. 1 hit.
TIGRFAMsi TIGR00126. deoC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiDEOC_MYCA1
AccessioniPrimary (citable) accession number: A0QLL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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