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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Mycobacterium avium (strain 104)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathway:i2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581Schiff-base intermediate with acetaldehydeUniRule annotation
Active sitei188 – 1881UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-4672-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:MAV_4672
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Deoxyribose-phosphate aldolasePRO_1000015324Add
BLAST

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 95Combined sources
Beta strandi12 – 154Combined sources
Helixi23 – 3614Combined sources
Beta strandi39 – 435Combined sources
Helixi45 – 473Combined sources
Helixi48 – 536Combined sources
Beta strandi60 – 656Combined sources
Turni66 – 683Combined sources
Helixi73 – 8513Combined sources
Beta strandi89 – 946Combined sources
Helixi97 – 1015Combined sources
Helixi105 – 11915Combined sources
Beta strandi122 – 1276Combined sources
Helixi130 – 1367Combined sources
Helixi139 – 15113Combined sources
Beta strandi155 – 1584Combined sources
Helixi171 – 18111Combined sources
Beta strandi184 – 1929Combined sources
Helixi196 – 2049Combined sources
Beta strandi208 – 2147Combined sources
Helixi215 – 2206Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NG3X-ray2.15A/B/C/D1-223[»]
ProteinModelPortaliA0QLL2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0QLL2.

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiGGDWDYV.
OrthoDBiEOG6QZMW5.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QLL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTRAQLAA FVDHTLLKPE ATAADVAALV TEAAELGVYA VCVSPPMVPA
60 70 80 90 100
AVQAGAGVRV ASVAGFPSGK HVSAVKAHEA ALAVASGAAE IDMVIDVGAA
110 120 130 140 150
LAGDLDGVRA DIAAVRGAVG GAVLKVIVES SALLALADEH TLVRVCRAAE
160 170 180 190 200
DAGADFVKTS TGFHPSGGAS VRAVALMAEA VGGRLGVKAS GGIRTAADAL
210 220
AMLDAGATRL GLSGTRAVLD GLG
Length:223
Mass (Da):21,723
Last modified:January 9, 2007 - v1
Checksum:i33A436559EB7FC1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67136.1.
RefSeqiWP_011726185.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK67136; ABK67136; MAV_4672.
KEGGimav:MAV_4672.
PATRICi17991042. VBIMycAvi38287_4590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67136.1.
RefSeqiWP_011726185.1. NC_008595.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NG3X-ray2.15A/B/C/D1-223[»]
ProteinModelPortaliA0QLL2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK67136; ABK67136; MAV_4672.
KEGGimav:MAV_4672.
PATRICi17991042. VBIMycAvi38287_4590.

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiGGDWDYV.
OrthoDBiEOG6QZMW5.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.
BioCyciMAVI243243:GH3Y-4672-MONOMER.

Miscellaneous databases

EvolutionaryTraceiA0QLL2.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiDEOC_MYCA1
AccessioniPrimary (citable) accession number: A0QLL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.