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Protein

Glutamate decarboxylase

Gene

MAV_4373

Organism
Mycobacterium avium (strain 104)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-4373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:MAV_4373Imported
OrganismiMycobacterium avium (strain 104)Imported
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_4373.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QKS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQHPSLPAH AIAPAYTGRL FTAPVPALRM PDESMDPDAA YRFIHDELML
60 70 80 90 100
DGSSRLNLAT FVTTWMDPEA GRLMAETFDK NMIDKDEYPA TAAIEQRCVC
110 120 130 140 150
MVADLFHAEG LNDADPYSAC GVSTIGSSEA VMLGGLAMKW RWRAKTKDWK
160 170 180 190 200
KRTPNLVMGS NVQVVWEKFC RYFDVEPRYL PMEEGRYVIT PEQVVDAVDE
210 220 230 240 250
DTIGVVAILG TTYTGELEPV ADICGALDKL AARGGVDVPV HVDAASGGFV
260 270 280 290 300
VPFLHPELKW DFRLPRVVSI NVSGHKYGLT YPGVGFVVWR SKEYLPDELV
310 320 330 340 350
FRVNYLGGDM PTFTLNFSRP GNQVVGQYYN FLRLGREGYT KVMQTLSGTA
360 370 380 390 400
RWLGEQLRVS EHCELISDGS AIPVVAFRLA KDRGYTEFDV SHELRTYGWQ
410 420 430 440 450
VPAYTMPDNA TDVSVLRIVV REGLSADLAR ALHDDAVSAL TSLDKVKPGG

HYDAQHFAH
Length:459
Mass (Da):50,991
Last modified:January 9, 2007 - v1
Checksum:i5CEC5F0DCF4C980E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67541.1.
RefSeqiYP_883508.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK67541; ABK67541; MAV_4373.
KEGGimav:MAV_4373.
PATRICi17990445. VBIMycAvi38287_4296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67541.1.
RefSeqiYP_883508.1. NC_008595.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243243.MAV_4373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK67541; ABK67541; MAV_4373.
KEGGimav:MAV_4373.
PATRICi17990445. VBIMycAvi38287_4296.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-4373-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104Imported.

Entry informationi

Entry nameiA0QKS0_MYCA1
AccessioniPrimary (citable) accession number: A0QKS0
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 1, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.