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A0QKR9

- ALR_MYCA1

UniProt

A0QKR9 - ALR_MYCA1

Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Active sitei273 – 2731Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei321 – 3211Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMAVI243243:GH3Y-4372-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr
    Ordered Locus Names:MAV_4372
    OrganismiMycobacterium avium (strain 104)
    Taxonomic identifieri243243 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000001574: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Alanine racemasePRO_1000066011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi243243.MAV_4372.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QKR9.
    SMRiA0QKR9. Positions 13-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiGHTWTAQ.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QKR9-1 [UniParc]FASTAAdd to Basket

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    MAVTPISLTP GVLAEALVDL GAIEHNVRLL CEQARGAQVM AVVKADGYGH    50
    GAVQTARAAL AAGAAELGVA TVDEALALRA AGISAPVLAW LHPPGIDFRP 100
    ALLAGVQIGL SSQRQLDELL TAVRDTGRTA TVTVKVDTGL NRNGVPPAQY 150
    PSMLTALRRA VAEQAIVPRG LMSHMVYADQ PANPVNDVQA QRFTDMLAQA 200
    REQGVRFEVA HLSNSSATMS RPDLAFDMVR PGIAVYGLSP VPELGDMGLV 250
    PAMTVKCTVA LVKSIRAGES VSYGHTWTAQ RDTNLALLPV GYADGIFRSL 300
    GGRLQVSING RRRPGVGRIC MDQFVVDLGP GRPDVAEGDE AILFGPGSNG 350
    EPTAQDWADL LGTIHYEVVT SPRGRITRTY REAHTVES 388
    Length:388
    Mass (Da):41,002
    Last modified:January 9, 2007 - v1
    Checksum:i1A978A3C7546CB2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK67912.1.
    RefSeqiYP_883507.1. NC_008595.1.

    Genome annotation databases

    EnsemblBacteriaiABK67912; ABK67912; MAV_4372.
    GeneIDi4527463.
    KEGGimav:MAV_4372.
    PATRICi17990443. VBIMycAvi38287_4295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK67912.1 .
    RefSeqi YP_883507.1. NC_008595.1.

    3D structure databases

    ProteinModelPortali A0QKR9.
    SMRi A0QKR9. Positions 13-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243243.MAV_4372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK67912 ; ABK67912 ; MAV_4372 .
    GeneIDi 4527463.
    KEGGi mav:MAV_4372.
    PATRICi 17990443. VBIMycAvi38287_4295.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi GHTWTAQ.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MAVI243243:GH3Y-4372-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 104.

    Entry informationi

    Entry nameiALR_MYCA1
    AccessioniPrimary (citable) accession number: A0QKR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3