A0QKN3 (A0QKN3_MYCA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	MAV_4335

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	1093 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0QKN3 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1E0264A02710BD6E	FASTA	1,093	118,204
	10 20 30 40 50 60 MGWFNGPPSW AEMERVLDSK PRRAGESPAP EPDGPLSRGR ATYRPPDEGR AARSSVPYAE 70 80 90 100 110 120 LHAHSAFSFL DGASTPEEMV EEAARLDLRA LALTDHDGLY GAVRFAEAAA ELDVRTVFGA 130 140 150 160 170 180 ELSLGPSART EAPDPPGPHL LVLARGPEGY RRLSRQLAAA HLAGGEKGKP RYDLDALTEA 190 200 210 220 230 240 AGGHWHILTG CRKGHVRQAL SEGGPDEAAR ALADLVDRFG AARVSIELTR HGQPLDDERN 250 260 270 280 290 300 AALAALAPRF GVGVVATTGA HFAGPSRRRL AMAVGAIRAR ESLDSAAGWL APLGGSHLRS 310 320 330 340 350 360 GEEMARLFAW CPEAVTAAAE LGEQCAFGLA LIAPRLPPFD VPDGHTEDSW LRQLTMTGAR 370 380 390 400 410 420 DRYGSPEHAP RAYAQIEHEL KVIAQLQFPG YFLVVHDIAR FCRENNILCQ GRGSAANSAV 430 440 450 460 470 480 CYALGVTAVD PVANELLFER FLSPARDGPP DIDMDIESDQ REKVIQYVYD RYGRDYAAQV 490 500 510 520 530 540 ANVITYRGKI AVRDMARALG FSQGQQDAWS KQISSWSGLA DSPDVEGIPP QVIDLANQVR 550 560 570 580 590 600 NLPRHLGIHS GGMVICDRPI ADVCPVEWAR MENRSVLQWD KDDCAAIGLV KFDLLGLGML 610 620 630 640 650 660 SALHYAIDLV AEHKGIEVDL ARLDLSEPAV YEMLARADSV GVFQVESRAQ MATLPRLKPR 670 680 690 700 710 720 VFYDLVVEVA LIRPGPIQGG SVHPYIRRRN GVDPVLYDHP SMEPALRKTL GVPLFQEQLM 730 740 750 760 770 780 QLAVDCAGFS AAEADQLRRA MGSKRSTERM RRLRGRFYDG MRALHGAPDE VIDRTYEKLE 790 800 810 820 830 840 AFANFGFPES HALSFASLVF YSSWFKLHHP AAFCAALLRA QPMGFYSPQS LVADARRHGV 850 860 870 880 890 900 TVHGPDVNAS LAHATLENAG TEVRLGLGAV RHIGDDLAEK LVQERKANGP FASLLDLTAR 910 920 930 940 950 960 LQLSVPQTEA LATAGAFGCF GMSRREALWA AGAAATQRPD RLPGVGSSSH IPALPGMSEL 970 980 990 1000 1010 1020 ELAAADVWAT GISPDSYPTQ FLRDDLDAMG VVPAARLGSV PDGDRVLIAG AVTHRQRPGT 1030 1040 1050 1060 1070 1080 AQGVTFLNLE DETGMVNVLC TPGVWARHRK LANTAPALLV RGQVQNASGA ITVVAERLGR 1090 ITLAVGSRSR DFR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK66972.1.
RefSeq	YP_883471.1. NC_008595.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0QKN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000011083; EBMYCP00000010969; EBMYCG00000011081.
GeneID	4526712.
GenomeReviews	Gene locus MAV_4335 in contig CP000479_GR.
KEGG	mav:MAV_4335.
PATRIC	17990371. VBIMycAvi38287_4259.
TIGR	MAV_4335.
Phylogenomic databases
eggNOG	COG0587.
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0QKN3_MYCA1

Accession

Primary (citable) accession number: A0QKN3

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)