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A0QJL0 (DNLI_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase
EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:MAV_3937
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) ›

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365221

Sites

Active site2301N6-AMP-lysine intermediate By similarity
Binding site2281ATP By similarity
Binding site2351ATP By similarity
Binding site2501ATP By similarity
Binding site2791ATP By similarity
Binding site3191ATP By similarity
Binding site3911ATP By similarity
Binding site3971ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QJL0 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 6AE14C9A8237CD2C

FASTA52654,705
        10         20         30         40         50         60 
MSPSHAKLAT VLLFDVATAS ADVGGTPSRL TKVARIADLL RRAAPDAALV AIVVSWLSGE 

        70         80         90        100        110        120 
LRQRQIGVGW AALRSRPPAA AHPTLTVVAV DAAFAEIGAV AGKGAQARRA ALLNALFAAA 

       130        140        150        160        170        180 
TETEQTFLLR LLGGELRQGA LAGIMADAVA RAAGIPAAAV QRAAMLGGDL PAVAAAALSG 

       190        200        210        220        230        240 
EAAALSGEAS ALDAFTLRVG RPVAPMLAQT AAGVAEAIER HGGQAIFEAK LDGARVQIHR 

       250        260        270        280        290        300 
AGDQVTVYTR SLDDVTARLP EVVTATLALP VEALIADGEA IALRPDNSPQ RFQVTASRFG 

       310        320        330        340        350        360 
RSVDVAAAVA AQPLSVFFFD ILHCDGVDLL DAPTTDRLAA LDALVPPAQR VDQLLTADPD 

       370        380        390        400        410        420 
AAGRFLEATL AAGHEGVMAK APGAPYQAGR RGAGWLKVKP VHTLDLVVLA VEWGSGRRRG 

       430        440        450        460        470        480 
KLSNIHLGAR DPATGEFVMV GKTFKGMTDA MLDWQTARFT ELAVGGTDGY VVRVRPEQVV 

       490        500        510        520 
EVAVDGVQKS SRYPGGLALR FARVLRYRDD KGPAEADTID AVRALY

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK65463.1.
RefSeqYP_883098.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QJL0.
ModBaseSearch...

Protein-protein interaction databases

STRING243243.MAV_3937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK65463; ABK65463; MAV_3937.
GeneID4530527.
KEGGmav:MAV_3937.
PATRIC17989562. VBIMycAvi38287_3858.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAARVQVHK.
ProtClustDBPRK03180.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-3937-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_MYCA1
AccessionPrimary (citable) accession number: A0QJL0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 9, 2007
Last modified: May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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