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A0QJB2 (DDL_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:MAV_3830
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000074777

Regions

Domain152 – 359208ATP-grasp
Nucleotide binding180 – 23556ATP By similarity

Sites

Metal binding3141Magnesium or manganese 1 By similarity
Metal binding3261Magnesium or manganese 1 By similarity
Metal binding3261Magnesium or manganese 2 By similarity
Metal binding3281Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QJB2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 052B24D16975D491

FASTA36938,902
        10         20         30         40         50         60 
MNASQRVRVA VVFGGRSNEH AISCVSAGSI LRNLDPRRFE VVAIGITPQG SWVLTDGDPA 

        70         80         90        100        110        120 
ALAISDRQLP EVTSASGTEL ALPADPGRSG QLVSLPPGAS EVLASVDVVF PVLHGPYGED 

       130        140        150        160        170        180 
GTIQGLLELA GVPYVGAGVF ASAAGMDKEF TKKLFAAEGL PIGDYAVLRP SQSTLSLQDR 

       190        200        210        220        230        240 
ERLGLPVFVK PARGGSSIGV SRVSSWDELD AAVAAARDHD PKVIVEAAIA GRELECGVLE 

       250        260        270        280        290        300 
MPDGTVQAST VGEIRVAGVR GREDSFYDFA TKYLDDTAEL DVPAKVDDEI ADAVRELAIR 

       310        320        330        340        350        360 
AFKAVDCQGL ARVDFFLTET GPVLNEINTM PGFTTISMYP RMWAASGVDY PSLLATMVET 


ALTRGVGLR 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000479 Genomic DNA. Translation: ABK66362.1.
RefSeqYP_883000.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QJB2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243243.MAV_3830.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK66362; ABK66362; MAV_3830.
GeneID4526488.
KEGGmav:MAV_3830.
PATRIC17989345. VBIMycAvi38287_3752.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-3831-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_MYCA1
AccessionPrimary (citable) accession number: A0QJB2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways