A0QJ41 (RNH2_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease HII
Short name=RNase HII
EC=3.1.26.4

Gene names

Name:	rnhB
Ordered Locus Names:	MAV_3757

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity. HAMAP MF_00052_B
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00052_B
Cofactor	Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00052_B.
Sequence similarities	Belongs to the RNase HII family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease H activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Ribonuclease HII HAMAP MF_00052_B		PRO_0000334924
Sites
	Metal binding	27	1	Divalent metal cation By similarity
	Metal binding	28	1	Divalent metal cation By similarity
	Metal binding	121	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QJ41 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 0FCDDA869057E68D	FASTA	230	24,217
	10 20 30 40 50 60 MIRKSSGLRT LESALYRSGL GPVAGVDEVG RGACAGPLVV AACVLGPGKL ESLAALDDSK 70 80 90 100 110 120 KLTESVRERL FPVIRRYALA YHVVFIPPAE VDRRGVHVAN IEGMRRAVAG LSLRPGYVLS 130 140 150 160 170 180 DGFRVPGLAV PSLPVIGGDA VAACIAAASV LAKVSRDRLM VAMDAEHPGY GFADHKGYST 190 200 210 220 230 PAHSAALARL GPCPQHRHSF INVRRVANGS GGRVVADCKP DLPLQRDEGR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK68212.1.
RefSeq	YP_882929.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QJ41.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QJ41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000010464; EBMYCP00000010350; EBMYCG00000010462.
GeneID	4529914.
GenomeReviews	Gene locus MAV_3757 in contig CP000479_GR.
KEGG	mav:MAV_3757.
PATRIC	17989197. VBIMycAvi38287_3678.
TIGR	MAV_3757.
Phylogenomic databases
eggNOG	COG0164.
GeneTree	EBGT00050000016477.
HOGENOM	HBG584843.
OMA	RLGPTPI.
PhylomeDB	A0QJ41.
ProtClustDB	PRK00015.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_3757-MONOMER.
Family and domain databases
HAMAP	MF_00052_B. RNase_HII_B. [Tree]
InterPro	IPR022898. RNase_HII. IPR001352. RNase_HII/HIII. IPR024567. RNase_HII/HIII_dom. IPR012337. RNaseH-like_dom. [Graphical view]
KO	K03470.
PANTHER	PTHR10954. RNase_HII/HIII. 1 hit.
Pfam	PF01351. RNase_HII. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNH2_MYCA1

Accession

Primary (citable) accession number: A0QJ41

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program