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A0QIW5

- PNP_MYCA1

UniProt

A0QIW5 - PNP_MYCA1

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, MAV_3676
Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi522 – 5221Magnesium By similarity
Metal bindingi528 – 5281Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-3676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:MAV_3676
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_3676.

Structurei

3D structure databases

ProteinModelPortaliA0QIW5.
SMRiA0QIW5. Positions 4-722.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini588 – 64760KHAdd
BLAST
Domaini659 – 72870S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QIW5-1 [UniParc]FASTAAdd to Basket

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MFEATATIDN GSFGTRTIRF ETGRLAQQAA GAVVAYLDDE NMLLSATTAS    50
KSPKEHFDFF PLTVDVEERM YAAGRIPGSF FRREGRPSTD AILTCRLIDR 100
PLRPSFVDGL RNEIQVVVTI LSLDPNDLYD VLAINAASAS TQLGGLPFSG 150
PIGGVRVALI DGTWVAFPTV EQLERAVFDM VVAGRKVDGA DGPDVAIMMV 200
EAEATSNVIE LIDGGAQAPT ETVVAQGLEA AKPFIEVLCT AQQELADKAA 250
RPTSDYPTFP DYGDDVYYSV ASVATDELSK ALTIGGKAER DARTDELKAE 300
VLARLAETYE GREKEVSAAF RSLTKKLVRQ RILTDHFRID GRGITDIRAL 350
SAEVAVVPRA HGSALFQRGE TQILGVTTLD MVKMAQQIDS LGPETTKRYM 400
HHYNFPPFST GETGRVGSPK RREIGHGALA ERALVPVLPS LEDFPYAIRQ 450
VSEALGSNGS TSMGSVCAST LALLNAGVPL KAPVAGIAMG LVSDDIEVEA 500
GDGTKSLERR FVTLTDILGA EDAFGDMDFK VAGTKDFVTA LQLDTKLDGI 550
PSQVLAGALS QAKDARLTIL EVMAEAIDEP DEMSPYAPRV TTIRVPVDKI 600
GEVIGPKGKI INAITEETGA QISIEDDGTV FVGATDGPSA QAAIDRINAI 650
ANPQLPTVGE RFLGTVVKTT DFGAFVSLLP GRDGLVHISK LGKGKRIAKV 700
EDVVNVGDKL RVEIADIDKR GKISLVLVEE DNSAPADAPA AAPADATS 748
Length:748
Mass (Da):79,598
Last modified:January 9, 2007 - v1
Checksum:iC334F4272B5D0EB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK69071.1.
RefSeqiWP_011725613.1. NC_008595.1.
YP_882853.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK69071; ABK69071; MAV_3676.
GeneIDi4526706.
KEGGimav:MAV_3676.
PATRICi17989032. VBIMycAvi38287_3596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK69071.1 .
RefSeqi WP_011725613.1. NC_008595.1.
YP_882853.1. NC_008595.1.

3D structure databases

ProteinModelPortali A0QIW5.
SMRi A0QIW5. Positions 4-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243243.MAV_3676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK69071 ; ABK69071 ; MAV_3676 .
GeneIDi 4526706.
KEGGi mav:MAV_3676.
PATRICi 17989032. VBIMycAvi38287_3596.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MAVI243243:GH3Y-3676-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiPNP_MYCA1
AccessioniPrimary (citable) accession number: A0QIW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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