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A0QIW5

- PNP_MYCA1

UniProt

A0QIW5 - PNP_MYCA1

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi522 – 5221MagnesiumUniRule annotation
Metal bindingi528 – 5281MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-3676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:MAV_3676
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Polyribonucleotide nucleotidyltransferasePRO_0000329715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_3676.

Structurei

3D structure databases

ProteinModelPortaliA0QIW5.
SMRiA0QIW5. Positions 4-722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini588 – 64760KHUniRule annotationAdd
BLAST
Domaini659 – 72870S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QIW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFEATATIDN GSFGTRTIRF ETGRLAQQAA GAVVAYLDDE NMLLSATTAS
60 70 80 90 100
KSPKEHFDFF PLTVDVEERM YAAGRIPGSF FRREGRPSTD AILTCRLIDR
110 120 130 140 150
PLRPSFVDGL RNEIQVVVTI LSLDPNDLYD VLAINAASAS TQLGGLPFSG
160 170 180 190 200
PIGGVRVALI DGTWVAFPTV EQLERAVFDM VVAGRKVDGA DGPDVAIMMV
210 220 230 240 250
EAEATSNVIE LIDGGAQAPT ETVVAQGLEA AKPFIEVLCT AQQELADKAA
260 270 280 290 300
RPTSDYPTFP DYGDDVYYSV ASVATDELSK ALTIGGKAER DARTDELKAE
310 320 330 340 350
VLARLAETYE GREKEVSAAF RSLTKKLVRQ RILTDHFRID GRGITDIRAL
360 370 380 390 400
SAEVAVVPRA HGSALFQRGE TQILGVTTLD MVKMAQQIDS LGPETTKRYM
410 420 430 440 450
HHYNFPPFST GETGRVGSPK RREIGHGALA ERALVPVLPS LEDFPYAIRQ
460 470 480 490 500
VSEALGSNGS TSMGSVCAST LALLNAGVPL KAPVAGIAMG LVSDDIEVEA
510 520 530 540 550
GDGTKSLERR FVTLTDILGA EDAFGDMDFK VAGTKDFVTA LQLDTKLDGI
560 570 580 590 600
PSQVLAGALS QAKDARLTIL EVMAEAIDEP DEMSPYAPRV TTIRVPVDKI
610 620 630 640 650
GEVIGPKGKI INAITEETGA QISIEDDGTV FVGATDGPSA QAAIDRINAI
660 670 680 690 700
ANPQLPTVGE RFLGTVVKTT DFGAFVSLLP GRDGLVHISK LGKGKRIAKV
710 720 730 740
EDVVNVGDKL RVEIADIDKR GKISLVLVEE DNSAPADAPA AAPADATS
Length:748
Mass (Da):79,598
Last modified:January 9, 2007 - v1
Checksum:iC334F4272B5D0EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK69071.1.
RefSeqiWP_011725613.1. NC_008595.1.
YP_882853.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK69071; ABK69071; MAV_3676.
GeneIDi4526706.
KEGGimav:MAV_3676.
PATRICi17989032. VBIMycAvi38287_3596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK69071.1 .
RefSeqi WP_011725613.1. NC_008595.1.
YP_882853.1. NC_008595.1.

3D structure databases

ProteinModelPortali A0QIW5.
SMRi A0QIW5. Positions 4-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243243.MAV_3676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK69071 ; ABK69071 ; MAV_3676 .
GeneIDi 4526706.
KEGGi mav:MAV_3676.
PATRICi 17989032. VBIMycAvi38287_3596.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MAVI243243:GH3Y-3676-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiPNP_MYCA1
AccessioniPrimary (citable) accession number: A0QIW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3