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A0QIL2 (DCUP_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:MAV_3573
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325664

Regions

Region34 – 385Substrate binding By similarity

Sites

Binding site831Substrate By similarity
Binding site1581Substrate By similarity
Binding site2131Substrate By similarity
Binding site3361Substrate By similarity
Site831Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QIL2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 78193A26B21B5EBB

FASTA35737,896
        10         20         30         40         50         60 
MNSSARTRRD LPESPYLAAV NGRKPHRVPV WFMRQAGRSL PEYRALRAQH DMLSACFDAE 

        70         80         90        100        110        120 
LVCEITLQPV RRHDVDAAIL FSDIVVPLLG AGIDLDIVAG VGPVIASPVR TAADVAAMKP 

       130        140        150        160        170        180 
LERQRVQPIA DAVRLLVSAL GEVPLIGFAG APFTLASYLI EGGPSRHHAR TKAMMLADPE 

       190        200        210        220        230        240 
SWHTLMEKLT DITVGFLRVQ LDAGVDAVQV FDSWAGALSL ANYRSYVQPH SARVFAALAD 

       250        260        270        280        290        300 
YGVPMTHFGV GTAELLGAMS AALKPAPATV VGVDWRTALA DAATRVMPGT ALQGNLDPVV 

       310        320        330        340        350 
LLAGWPVVET AARAVVDDGR RAVDAGAAGH VFNLGHGVLP ETDPGVLTEL VSLVHSL

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK68910.1.
RefSeqYP_882750.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QIL2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QIL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000010334; EBMYCP00000010220; EBMYCG00000010332.
GeneID4530664.
GenomeReviewsGene locus MAV_3573 in contig CP000479_GR.
KEGGmav:MAV_3573.
PATRIC17988826. VBIMycAvi38287_3493.
TIGRMAV_3573.

Phylogenomic databases

eggNOGCOG0407.
GeneTreeEBGT00050000016469.
HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBA0QIL2.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycMAVI243243:MAV_3573-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_MYCA1
AccessionPrimary (citable) accession number: A0QIL2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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