A0QI37 (PYRB_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	MAV_3393

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301589

Sequences

	Sequence		Length	Mass (Da)
	A0QI37 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 258F21580F8E6852	FASTA	318	33,593
	10 20 30 40 50 60 MTRHLLAAGD LSRDDATAIL DDADRFAQAL VGREIKKLPT LRGRTVVTMF YENSTRTRVS 70 80 90 100 110 120 FEVAGKWMSA DVINVSAAGS SVGKGESLRD TALTLRAAGA DALIIRHPAS GAAHLLAEWT 130 140 150 160 170 180 CGNGDSSDAG PSVINAGDGT HEHPTQALLD ALTIRQRLGG IEGRRVVIVG DVLHSRVARS 190 200 210 220 230 240 NVMLLSTLGA EVVLVAPPTL LPVGVEGWPV TVSNDFDAEL PAADAVLMLR VQAERMNGGF 250 260 270 280 290 300 FPSVREYSSL YGLSDRRQAM LPGHAVVLHP GPMLRGMEIA SSVADSSQSA VLQQVSNGVH 310 VRMAVLFHVL VGAEEIAA

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK66201.1.
RefSeq	YP_882575.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QI37.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QI37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000010683; EBMYCP00000010569; EBMYCG00000010681.
GeneID	4528813.
GenomeReviews	Gene locus MAV_3393 in contig CP000479_GR.
KEGG	mav:MAV_3393.
PATRIC	17988475. VBIMycAvi38287_3322.
TIGR	MAV_3393.
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000016463.
HOGENOM	HBG579429.
OMA	LQRERMS.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_3393-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_MYCA1

Accession

Primary (citable) accession number: A0QI37

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program