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A0QI32

- PYRF_MYCA1

UniProt

A0QI32 - PYRF_MYCA1

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciMAVI243243:GH3Y-3388-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:MAV_3388
    OrganismiMycobacterium avium (strain 104)
    Taxonomic identifieri243243 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000001574: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_1000066476Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243243.MAV_3388.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QI32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245748.
    KOiK01591.
    OMAiGSTMGAY.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QI32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGFGARLAA AKAQRGPLCV GIDPHPELLR AWDLPTTADG LAAFCDICVE    50
    AFAGFAVVKP QVAFFEAYGA AGFAVLERTI AALRSAGVLV LADAKRGDIG 100
    TTMAAYAAAW AGDSPLAADA VTASPYLGFG SLRPLLEAAA AHDRGVFVLA 150
    ATSNPEGATV QRAAFDGRTV AQLVVDQAAV VNRSTNPAGP GYVGVVVGAT 200
    VLQPPDLSAL GGPVLVPGLG VQGGRPEALA GLGGAEPGQL LPAVAREVLR 250
    AGPDVAELRG AADRMLDAVA YLDV 274
    Length:274
    Mass (Da):27,534
    Last modified:January 9, 2007 - v1
    Checksum:i4103AD95DD1E2E0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK68289.1.
    RefSeqiWP_011725440.1. NC_008595.1.
    YP_882570.1. NC_008595.1.

    Genome annotation databases

    EnsemblBacteriaiABK68289; ABK68289; MAV_3388.
    GeneIDi4527734.
    KEGGimav:MAV_3388.
    PATRICi17988465. VBIMycAvi38287_3317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK68289.1 .
    RefSeqi WP_011725440.1. NC_008595.1.
    YP_882570.1. NC_008595.1.

    3D structure databases

    ProteinModelPortali A0QI32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243243.MAV_3388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK68289 ; ABK68289 ; MAV_3388 .
    GeneIDi 4527734.
    KEGGi mav:MAV_3388.
    PATRICi 17988465. VBIMycAvi38287_3317.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245748.
    KOi K01591.
    OMAi GSTMGAY.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci MAVI243243:GH3Y-3388-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 104.

    Entry informationi

    Entry nameiPYRF_MYCA1
    AccessioniPrimary (citable) accession number: A0QI32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3