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A0QHY4

- PGK_MYCA1

UniProt

A0QHY4 - PGK_MYCA1

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431SubstrateUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei215 – 2151ATPUniRule annotation
    Binding sitei303 – 3031ATP; via carbonyl oxygenUniRule annotation
    Binding sitei334 – 3341ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi363 – 3664ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMAVI243243:GH3Y-3340-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:MAV_3340
    OrganismiMycobacterium avium (strain 104)
    Taxonomic identifieri243243 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000001574: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Phosphoglycerate kinasePRO_1000009629Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243243.MAV_3340.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QHY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingUniRule annotation
    Regioni66 – 694Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiHASVYDI.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QHY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVHNLKDLL AEGVSGRGVL VRSDLNVPLD SDGEQGRITD PGRITASVPT    50
    LSALVEAGAK VVVAAHLGRP KNGPDPALSL APVAAALGEQ LGRHVQLASD 100
    VVGTDALARA EGLTDGDVLL LENIRFDARE TSKDDAERLA LARQLAELVG 150
    PTGAFVSDGF GVVHRKQASV YDVATLLPHY AGTLVAEEIA VLEQLTGSTK 200
    RPYAVVLGGS KVSDKLGVIE SLATKADSIV IGGGMCFTFL AAQGFSVGKS 250
    LLETEMVDTC RRLLDTYVDV LRLPVDIVAA DRFAADAAPQ TVPADAIPDD 300
    LMGLDIGPGS VKRFTALLSN AETIFWNGPM GVFEFPAFAA GTKGLAEAIA 350
    AATGKGAFSV VGGGDSAAAV RALGIPESGF SHISTGGGAS LEYLEGKALP 400
    GIEVLGRPQP TGGAA 415
    Length:415
    Mass (Da):42,437
    Last modified:January 9, 2007 - v1
    Checksum:iA66A383F0A73530B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK68540.1.
    RefSeqiYP_882522.1. NC_008595.1.

    Genome annotation databases

    EnsemblBacteriaiABK68540; ABK68540; MAV_3340.
    GeneIDi4530496.
    KEGGimav:MAV_3340.
    PATRICi17988367. VBIMycAvi38287_3268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK68540.1 .
    RefSeqi YP_882522.1. NC_008595.1.

    3D structure databases

    ProteinModelPortali A0QHY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243243.MAV_3340.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK68540 ; ABK68540 ; MAV_3340 .
    GeneIDi 4530496.
    KEGGi mav:MAV_3340.
    PATRICi 17988367. VBIMycAvi38287_3268.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi HASVYDI.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci MAVI243243:GH3Y-3340-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 104.

    Entry informationi

    Entry nameiPGK_MYCA1
    AccessioniPrimary (citable) accession number: A0QHY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3