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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium avium (strain 104)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611UniRule annotation
Active sitei593 – 5931UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-3336-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:MAV_3336
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 935935Phosphoenolpyruvate carboxylasePRO_1000025565Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QHY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEASEGTLE PIGAVQRTLV GREATEPMRA DIGLLGAILG DTVREQNGQQ
60 70 80 90 100
VFELVERARV ESFRVRRSEI DRAELARMFA GIDIHQAIPV IRAFSHFALL
110 120 130 140 150
ANVAEDIHRE RRRAIHVAAG EPPQDSSLAA TYAKLDRAQL DSATVAEALR
160 170 180 190 200
GAVVSPVITA HPTETRRRTV FVTQHRITEL MRLHAEGHIE TDDGRNIELE
210 220 230 240 250
LRRQVLTLWQ TALIRLSRLQ ITDEIEVGLR YYAAAFFKVI PRVNAEVRNA
260 270 280 290 300
LRARWPGADL LDEPIVAPGS WIGGDRDGNP NVTADVVRRA TGDAAYTALA
310 320 330 340 350
HYLAELTACE QELSMSARLV AVTPELAALA EDCAEKARAD EPYRRALRVI
360 370 380 390 400
RGRLTATAAE ILDRRPQHEL DLGLPPYATP AELRGDLDTV DASLRAHGSA
410 420 430 440 450
LLADDRLALL REGVRVFGFH LCGLDMRQNS DVHEEVVAEL LAWAGVHPDY
460 470 480 490 500
RSLPEDERVE LLAAELGTRR PLVGDRAELS ELADKELGVV RAAAHAIRRY
510 520 530 540 550
GPAAVPNYVI SMCRSVSDVL EAAILLKEAG LIDASGPEPY CPVGISPLFE
560 570 580 590 600
TIEDLHNGAA ILHAMLELPL YRALVAARGQ SQEVMLGYSD SNKDGGYLAS
610 620 630 640 650
SWAVYRAELA LVEVARKTGI RLRLFHGRGG TVGRGGGPSY EAILAQPPGA
660 670 680 690 700
VNGSLRLTEQ GEVIAAKYAE PQVAQRNLES LVAATLESTL LDVEGLGDTA
710 720 730 740 750
EPAYAVLDEV AVLAQRAYAE LVHETPGFVD YFMASTPVSE IGSLNIGSRP
760 770 780 790 800
TSRKPTESIA DLRAIPWVLA WSQSRVMLPG WYGTGSAFEQ WIAAGPQSRA
810 820 830 840 850
ERVDILHDLY RRWPFFRSVL SNLAQVLAKS DLGLAAQYAE LVDDAALRRR
860 870 880 890 900
VFGKIADEHR RTIAMHKLIT GQDNLLADNP ALARSVFNRF PYLEPLNHLQ
910 920 930
VELLRRYRSG DDDELVQRGI LLTMNGLTSA LRNSG
Length:935
Mass (Da):102,548
Last modified:January 9, 2007 - v1
Checksum:iDF4E7779B3A41F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67960.1.
RefSeqiWP_011725407.1. NC_008595.1.
YP_882518.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK67960; ABK67960; MAV_3336.
KEGGimav:MAV_3336.
PATRICi17988359. VBIMycAvi38287_3264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67960.1.
RefSeqiWP_011725407.1. NC_008595.1.
YP_882518.1. NC_008595.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK67960; ABK67960; MAV_3336.
KEGGimav:MAV_3336.
PATRICi17988359. VBIMycAvi38287_3264.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-3336-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiCAPP_MYCA1
AccessioniPrimary (citable) accession number: A0QHY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: June 24, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.