A0QHX0 (COXX_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protoheme IX farnesyltransferase
EC=2.5.1.-

Alternative name(s):
Heme B farnesyltransferase
Heme O synthase

Gene names

Name:	ctaB
Ordered Locus Names:	MAV_3326

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) › Mycobacterium avium

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity. HAMAP-Rule MF_00154
Pathway	Porphyrin metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. HAMAP-Rule MF_00154
Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_00154.
Miscellaneous	Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity. HAMAP-Rule MF_00154
Sequence similarities	Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
Sequence caution	The sequence ABK64550.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Heme biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	heme O biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protoheme IX farnesyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Protoheme IX farnesyltransferase HAMAP-Rule MF_00154		PRO_0000327081
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Transmembrane	124 – 144	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	170 – 190	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential
	Transmembrane	288 – 308	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A0QHX0 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: F0104B69FBCFEA58	FASTA	308	33,288
	10 20 30 40 50 60 MSVRGRVAPS QTPSRIPGTV LAYLALTKPR VIELLLVTAI PAMLLAQRGT VNPLLIVNTL 70 80 90 100 110 120 IGGMLAAGGA NALNCVADAD IDKVMKRTAR RPLARAAVPT RNALVFGLVL TAGSFLWLWW 130 140 150 160 170 180 TTNLLSGLLA LATIAFYVFI YTLLLKRRTS QNVVWGGAAG CMPVMIGWSA VTGTIQWPAL 190 200 210 220 230 240 VMFAIIFFWT PPHTWALAMR YKDDYKAAGV PMLPAVATER QVTKQILVYT WLTVLATLAL 250 260 270 280 290 300 ALATGWLYAA VAVVAGVWFL AMAHQLYAGV RAGEPVKPLR LFLQSNNYLA VVFCALAIDS AIGLPHLF

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK64550.1. Different initiation.
RefSeq	YP_882508.1. NC_008595.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	243243.MAV_3326.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK64550; ABK64550; MAV_3326.
GeneID	4529178.
KEGG	mav:MAV_3326.
PATRIC	17988339. VBIMycAvi38287_3254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0109.
HOGENOM	HOG000237291.
KO	K02301.
ProtClustDB	PRK04375.
Enzyme and pathway databases
BioCyc	MAVI243243:GH3Y-3340-MONOMER.
UniPathway	UPA00834; UER00712.
Family and domain databases
HAMAP	MF_00154. CyoE_CtaB.
InterPro	IPR006369. Protohaem_IX_farnesylTrfase. IPR000537. UbiA_prenyltransferase. [Graphical view]
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01473. cyoE_ctaB. 1 hit.
PROSITE	PS00943. UBIA. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COXX_MYCA1

Accession

Primary (citable) accession number: A0QHX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program