A0QHK6 (A0QHK6_MYCA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malto-oligosyltrehalose trehalohydrolase PIRNR PIRNR006337
Short name=MTHase PIRNR PIRNR006337
EC=3.2.1.141 PIRNR PIRNR006337

Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase PIRNR PIRNR006337
Maltooligosyl trehalose trehalohydrolase PIRNR PIRNR006337

Gene names

Name:	treZ EMBL ABK68344.1
Ordered Locus Names:	MAV_3212

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	590 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan. PIRNR PIRNR006337
Pathway	Glycan biosynthesis; trehalose biosynthesis. PIRNR PIRNR006337
Subcellular location	Cytoplasm By similarity PIRSR PIRSR006337-1.
Sequence similarities	Belongs to the glycosyl hydrolase 13 family. PIRNR PIRNR006337

Ontologies

Keywords
Molecular function	Glycosidase PIRNR PIRNR006337 EMBL ABK68344.1 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	248	1	Nucleophile By similarity PIRSR PIRSR006337-1
	Active site	285	1	Proton donor By similarity PIRSR PIRSR006337-1
	Site	384	1	Transition state stabilizer By similarity PIRSR PIRSR006337-3

Sequences

	Sequence		Length	Mass (Da)
	A0QHK6 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 23484A6DFFFDD4F7	FASTA	590	65,232
	10 20 30 40 50 60 MTEQKTEFRV WAPKPARVRL DVEGRPHAMS RTDDGWWHAA VACAPDARYG FLLDDDPTVL 70 80 90 100 110 120 PDPRSPRQPE GVHARSQLWD PAAATWTDSA WPGRSTHGAV IYELHLGTFT AAGTFDSAIE 130 140 150 160 170 180 KLDYLVDLGV DFVELMPVNS FAGTRGWGYD GVLWYSVHEP YGGPDGLVRF VDACHARGLG 190 200 210 220 230 240 VLIDAVFNHL GPSGNYLPRF GPYLSSASNP WGEGINIADA DSDEVRRYII GCALRWMRDF 250 260 270 280 290 300 HADGLRLDAV HALVDTTAIH ILEELATETD WLATQLGRPL SLIAESDLND PRLITARERG 310 320 330 340 350 360 GYGLTAQWAD DIHHAIHTAV SGERQGYYAD FGSIATLAHT LRHGYFHAAT YSSFRRRRHG 370 380 390 400 410 420 RPLDTSAQTG IPATRLLAYT CTHDQVGNRA LGDRPSQNLT AGQLAVKAVL ALLSPYTAML 430 440 450 460 470 480 FMGEEYGAST PFQFFSSHPE PELARATAEG RKTEFAEHGW DASKKGEIPD PQDPQTFARS 490 500 510 520 530 540 KLNWDEVGTG EHARLHRLYR DLIALRHNDP DLADPWLEHL TVDYDEDQRW IVLARGRLRI 550 560 570 580 590 VCNLGAEPVT VPVGGELMLA WDEPTVDADT TALQGHSFAI LSTPGQPVDN

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK68344.1.
RefSeq	YP_882394.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QHK6.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QHK6.
Protein family/group databases
CAZy	CBM48. Carbohydrate-Binding Module Family 48. GH13. Glycoside Hydrolase Family 13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000011855; EBMYCP00000011741; EBMYCG00000011853.
GeneID	4528782.
GenomeReviews	Gene locus MAV_3212 in contig CP000479_GR.
KEGG	mav:MAV_3212.
PATRIC	17988119. VBIMycAvi38287_3144.
TIGR	MAV_3212.
Phylogenomic databases
eggNOG	COG0296.
GeneTree	EBGT00050000016657.
HOGENOM	HBG367595.
OMA	EGFVYQG.
ProtClustDB	CLSK799816.
Family and domain databases
InterPro	IPR015902. Alpha_amylase. IPR006047. Glyco_hydro_13_cat_dom. IPR004193. Glyco_hydro_13_N. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR022567. Maltooligo_trehalose_bac_C. IPR012768. Trehalose_TreZ. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits. G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K01236.
PANTHER	PTHR10357. Alpha_amylase. 1 hit. PTHR10357:SF21. PTHR10357:SF21. 1 hit.
Pfam	PF00128. Alpha-amylase. 1 hit. PF02922. CBM_48. 1 hit. PF11941. DUF3459. 1 hit. [Graphical view]
PIRSF	PIRSF006337. Trehalose_TreZ. 1 hit.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit. SSF81296. Ig_E-set. 1 hit.
TIGRFAMs	TIGR02402. Trehalose_TreZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0QHK6_MYCA1

Accession

Primary (citable) accession number: A0QHK6

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)