Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

8-amino-7-oxononanoate synthase

Gene

MAV_3205

Organism
Mycobacterium avium (strain 104)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 271SubstrateBy similarity
Binding sitei130 – 1301SubstrateBy similarity
Binding sitei176 – 1761Pyridoxal phosphateBy similarity
Binding sitei345 – 3451SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-3205-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:MAV_3205
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000001574 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3813818-amino-7-oxononanoate synthasePRO_0000381033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA0QHJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1062Pyridoxal phosphate bindingBy similarity
Regioni201 – 2044Pyridoxal phosphate bindingBy similarity
Regioni232 – 2354Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000221021.
KOiK00652.
OMAiIAPYDFY.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QHJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPIEVSPL AWLDAVEQQR RAAGLRRSLR PRPPVATELD LASNDYLGLS
60 70 80 90 100
QHPDVIDGGV AALRLWGAGA TGSRLVTGDT ELHQQFESEL ADYVGAASGL
110 120 130 140 150
LFSSGYAANL GAVVGLSGRG ALVVSDAYSH ASLVDACRLS RARVVVTPHR
160 170 180 190 200
DVDAVLAALA DRDEERAVVI TESVFSTDGA LAPLRELHEV CRRHRALLIV
210 220 230 240 250
DEAHGLGVRG GGRGLVFEAG LAGAPDVVMT TTLSKALGSQ GGAVLGPAAV
260 270 280 290 300
RAHLIDAART FIFDTGLAPA AVGAARAALG VLRAEPWRVG AVLRHAGVLA
310 320 330 340 350
EVCRVREVPQ SAVVSVILGD PDVAVAAATA CLDAGVRVGC FRPPTVPAGT
360 370 380
SRLRLTARAS LDDAELEVAR RVLTDVLAGL G
Length:381
Mass (Da):39,376
Last modified:January 9, 2007 - v1
Checksum:iF615222D4D079E61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK65140.1.
RefSeqiWP_011725323.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK65140; ABK65140; MAV_3205.
KEGGimav:MAV_3205.
PATRICi17988105. VBIMycAvi38287_3137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK65140.1.
RefSeqiWP_011725323.1. NC_008595.1.

3D structure databases

ProteinModelPortaliA0QHJ9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK65140; ABK65140; MAV_3205.
KEGGimav:MAV_3205.
PATRICi17988105. VBIMycAvi38287_3137.

Phylogenomic databases

HOGENOMiHOG000221021.
KOiK00652.
OMAiIAPYDFY.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciMAVI243243:GH3Y-3205-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOF_MYCA1
AccessioniPrimary (citable) accession number: A0QHJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.