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A0QHI1 (HIS8_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene names
Name:hisC
Ordered Locus Names:MAV_3186
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) ›

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP-Rule MF_01023

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01023

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP-Rule MF_01023

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01023

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Histidinol-phosphate aminotransferase HAMAP-Rule MF_01023
PRO_0000319775

Amino acid modifications

Modified residue2341N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QHI1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: EE095528B921DFC7

FASTA39842,166
        10         20         30         40         50         60 
MTGQRATPQP TLDDLPLRDD LRGKSPYGAP QLAVPVRLNT NENPHPPSRA LVDDVVRSVA 

        70         80         90        100        110        120 
RAAADLHRYP DRDAVQLRSD LARYLTAQTG VQLGVENLWA ANGSNEILQQ LLQAFGGPGR 

       130        140        150        160        170        180 
SAIGFVPSYS MHPIISDGTR TEWLQAARAD DFSLDVDAAV AAVTERTPDV VFVASPNNPS 

       190        200        210        220        230        240 
GQSVSLSGLR RLLDAAPGIV IVDEAYGEFS SQPSAVQLVG EYPTKLVVTR TMSKAFAFAG 

       250        260        270        280        290        300 
GRLGYLIATP AVIEAMLLVR LPYHLSSVTQ AAARAALRHA DDTLGSVAAL IAERERVSTA 

       310        320        330        340        350        360 
LTGMGFRVIP SDANFVLFGE FTDAPASWQR YLDAGVLIRD VGIPGYLRAT TGLAEENDAF 

       370        380        390 
LRASAQLAAT ELAPVNVGAI ASAAEPRAAG RDHVLGAP

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK68288.1.
RefSeqYP_882369.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QHI1.
SMRA0QHI1. Positions 11-372.
ModBaseSearch...

Protein-protein interaction databases

STRING243243.MAV_3186.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK68288; ABK68288; MAV_3186.
GeneID4527733.
KEGGmav:MAV_3186.
PATRIC17988065. VBIMycAvi38287_3117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0079.
HOGENOMHOG000288510.
KOK00817.
OMAGRSAMGF.
ProtClustDBPRK03317.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-3186-MONOMER.
UniPathwayUPA00031; UER00012.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01023. HisC_aminotrans_2.
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01141. hisC. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS8_MYCA1
AccessionPrimary (citable) accession number: A0QHI1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: May 29, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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