A0QHB4 (ARGC_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	MAV_3118

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011020
Sites
	Active site	153	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QHB4 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 244743B0ACE788C6	FASTA	347	35,261
	10 20 30 40 50 60 MADVMRVAVA GASGYAGGEI LRLLLGHPAY AQGRLTIGAV TAAASAGSPL GEHHPHLTPL 70 80 90 100 110 120 AQRVLEPTDA AVLAGHDVVF LALPHGHSAA LADQLGADTL IVDCGADFRL TDAAAWERFY 130 140 150 160 170 180 GAPHAGSWPY GLPELPGARE RLRGARRIAV PGCYPTAALL ALLPAMAEDL IEPAVTVVAV 190 200 210 220 230 240 SGTSGAGRAA KTDLLGSEVI GSARAYNIAG AHRHTPEIAQ GLAAVSGRDV TVSFTPVLIP 250 260 270 280 290 300 TSRGILATCT ARTTAPLSAL RAAYEKTYDA EPFIYLMPEG QLPRTGAVIG SNAAHIAVAV 310 320 330 340 DEAAGVLVAI AAIDNLVKGT AGAAVQSMNL ALGWPETQGL SVIGVAP

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK69131.1.
RefSeq	YP_882302.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QHB4.
SMR	A0QHB4. Positions 1-347.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QHB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000009125; EBMYCP00000009011; EBMYCG00000009123.
GeneID	4530259.
GenomeReviews	Gene locus MAV_3118 in contig CP000479_GR.
KEGG	mav:MAV_3118.
PATRIC	17987927. VBIMycAvi38287_3049.
TIGR	MAV_3118.
Phylogenomic databases
eggNOG	COG0002.
GeneTree	EBGT00050000015828.
HOGENOM	HBG294213.
OMA	VCRIAVH.
PhylomeDB	A0QHB4.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_3118-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_MYCA1

Accession

Primary (citable) accession number: A0QHB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program