A0QHA7 (ARLY_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	MAV_3111

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000504

Sequences

	Sequence		Length	Mass (Da)
	A0QHA7 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: E3508731CC432B73	FASTA	472	49,739
	10 20 30 40 50 60 MSTREGSLWG GRFADGPSDA LAALSKSTHF DWVLAPYDIV ASRAHTVILY RAGLLSEEQR 70 80 90 100 110 120 DGLLAGLDSL AEDVADGSFT PLVTDEDVHA ALERGLIDRV GPDLGGRLRA GRSRNDQVAT 130 140 150 160 170 180 LFRMWLRDAV RRVAAGALDV VGALVAQAAA HPEAIMPGKT HLQSAQPVLL AHHLLAHAHP 190 200 210 220 230 240 LLRDVDRIVD FDKRAAVSPY GSGALAGSSL GLDPDAIAAE LGFASAADNS IDATASRDFA 250 260 270 280 290 300 AEAAFVFAMI GVDLSRLAED VILWSSTEFG YVKLHDAWST GSSIMPQKKN PDIAELARGK 310 320 330 340 350 360 SGRLIGNLAG LLATLKAQPL AYNRDLQEDK EPVFDAVAQL ELVLPAMAGL VGSLTFDVQR 370 380 390 400 410 420 MAALAPAGYT LATDIAEWLV RQGVPFRSAH EAAGAAVRAA EQRAVGLDEL TDDELAAISP 430 440 450 460 470 ALTPQVREVL TIEGSVSSRD ARGGTAPARV VEQIDTVAAT AARLRERLGG PA

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK64487.1.
RefSeq	YP_882295.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QHA7.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QHA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000010886; EBMYCP00000010772; EBMYCG00000010884.
GeneID	4525648.
GenomeReviews	Gene locus MAV_3111 in contig CP000479_GR.
KEGG	mav:MAV_3111.
PATRIC	17987913. VBIMycAvi38287_3042.
TIGR	MAV_3111.
Phylogenomic databases
eggNOG	COG0165.
GeneTree	EBGT00050000016253.
HOGENOM	HBG539632.
OMA	MPGRTHL.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_3111-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_MYCA1

Accession

Primary (citable) accession number: A0QHA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program