A0QH59 (DER_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Der

Alternative name(s):
GTP-binding protein EngA

Gene names

Name:	der
Synonyms:	engA
Ordered Locus Names:	MAV_3063

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195
Subunit structure	Associates with the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Der subfamily. Contains 2 G (guanine nucleotide-binding) domains. Contains 1 KH-like domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Domain	Repeat
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	GTPase Der HAMAP MF_00195		PRO_1000011667
Regions
	Domain	41 – 146	106	G 1
	Domain	214 – 322	109	G 2
	Domain	376 – 459	84	KH-like
	Nucleotide binding	36 – 43	8	GTP 1 Potential
	Nucleotide binding	83 – 87	5	GTP 1 Potential
	Nucleotide binding	145 – 148	4	GTP 1 Potential
	Nucleotide binding	209 – 216	8	GTP 2 Potential
	Nucleotide binding	256 – 260	5	GTP 2 Potential
	Nucleotide binding	321 – 324	4	GTP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	A0QH59 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 470014E155BF0455	FASTA	466	50,663
	10 20 30 40 50 60 MTHDGTWSDE SDWEAVEFEL DEAAQAPPAP VVAVVGRPNV GKSTLVNRIL GRREAVVQDV 70 80 90 100 110 120 PGVTRDRVSY DALWTGRRFV VQDTGGWEPD AKGLQQLVAE QASVAMRTAD AVILVVDALV 130 140 150 160 170 180 GATTADEAAA RILLRSGKPV FLAANKVDSD KAEADAAMLW SLGLGEPHPI SAMHGRGVAD 190 200 210 220 230 240 LLDEVLAALP EVSEVAPRPG GPRRVALVGK PNVGKSSLLN KLAGDQRSVV HDVAGTTVDP 250 260 270 280 290 300 VDSLIELGDR VWRFVDTAGL RRKVGQASGH EFYASVRTHS AIDAAEVVIV LIDASAPLTE 310 320 330 340 350 360 QDQRVLSMVI EAGRALVLAF NKWDLVDEDR RELLEREIDR ELVQLRWAPR VNISAKTGRA 370 380 390 400 410 420 VAKLVPAMET ALASWDTRIA TGPLNSWLKE VVAATPPPVR GGKQPRILFA TQAAARPPTF 430 440 450 460 VLFTTGFLEA GYRRFLERRL REAFGFEGTP IRINVRVREK RGARRR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK64761.1.
RefSeq	YP_882247.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QH59.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QH59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000010450; EBMYCP00000010336; EBMYCG00000010448.
GeneID	4530197.
GenomeReviews	Gene locus MAV_3063 in contig CP000479_GR.
KEGG	mav:MAV_3063.
PATRIC	17987819. VBIMycAvi38287_2995.
TIGR	MAV_3063.
Phylogenomic databases
eggNOG	COG1160.
GeneTree	EBGT00050000016947.
HOGENOM	HBG592135.
OMA	LAVNKCE.
ProtClustDB	PRK03003.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_3063-MONOMER.
Family and domain databases
HAMAP	MF_00195. GTPase_Der. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR016484. GTP-bd_EngA. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR005225. Small_GTP-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
KO	K03977.
PANTHER	PTHR11649:SF5. PTHR11649:SF5. 1 hit.
Pfam	PF01926. MMR_HSR1. 2 hits. [Graphical view]
PIRSF	PIRSF006485. GTP-binding_EngA. 1 hit.
PRINTS	PR00326. GTP1OBG.
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR03594. GTPase_EngA. 1 hit. TIGR00231. Small_GTP. 2 hits.
ProtoNet	Search...

Entry information

Entry name

DER_MYCA1

Accession

Primary (citable) accession number: A0QH59

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program