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A0QGN2

- GCSP_MYCA1

UniProt

A0QGN2 - GCSP_MYCA1

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, MAV_2884
Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-2884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:MAV_2884
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei692 – 6921N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi243243.MAV_2884.

Structurei

3D structure databases

ProteinModelPortaliA0QGN2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QGN2-1 [UniParc]FASTAAdd to Basket

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MPDHTTFAAR HIGPDPQAVA AMLDVIGVGS LDELAAKAVP AGIRDRLSAD    50
GIAPGLDRLP PPASETEALA ELRGLAEANT VAVSMIGQGY YDTLTPPVLL 100
RNILENPAWY TAYTPYQPEI SQGRLEALLN FQTMVADLTG LEIANASMLD 150
EGTAAAEAMT LMHRASRGKS NRLAVDVDVF AQTAAIVATR ARPLGIEIVT 200
ADLRDGLPDG DFFGVIAQLP GASGAITDWA ALVAQAHERG ALVALGADLL 250
ALTLITPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH ANHARQLPGR 300
LVGVSLDADG SPAYRLALQT REQHIRRDKA TSNICTAQVL LAVMAAMYAS 350
YHGAEGLTAI ARRVHGHAEA IAAALGTAVV HDRYFDTVLA RVPGRAHEVI 400
AAAKARGINL WRVDDDHVSV ACDEATTDEH VAAVLEAFGV APAEPVASEI 450
ATRTSEFLTH PAFTQYRTET AMMRYLRTLA DKDIALDRSM IPLGSCTMKL 500
NAAAEMEPIT WPEFARQHPF APASDTPGLR RLIGDLENWL VAITGYDAVS 550
LQPNAGSQGE YAGLLAIHDY HASRGEPHRD ICLIPSSAHG TNAASAALAG 600
MRVVVVGCHD NGDVDLDDLR AKVTDHRDRL STLMITYPST HGVYEHDIAE 650
ICAAVHDAGG QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG 700
GGPGVGPVAV RSHLAPFLPG HPHAPELPQG HPVSSAPYGS ASILPISWAY 750
IRMMGADGLR AASLTAITSA NYIARRLDEY FPVLYTGENG MVAHECILDL 800
RPITKATGVT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP TESETLTEVD 850
AFCDAMIAIR GEIDRVGAGE WPVEDNPLRG APHTAECLVT TDWDHPYSRE 900
QAAYPLGKDF RPKVWPPVRR IDGAYGDRNL VCSCPPVEAF A 941
Length:941
Mass (Da):99,961
Last modified:January 9, 2007 - v1
Checksum:iD8668C4BC2C65BCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK68698.1.
RefSeqiYP_882070.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK68698; ABK68698; MAV_2884.
GeneIDi4527187.
KEGGimav:MAV_2884.
PATRICi17987461. VBIMycAvi38287_2817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK68698.1 .
RefSeqi YP_882070.1. NC_008595.1.

3D structure databases

ProteinModelPortali A0QGN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243243.MAV_2884.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK68698 ; ABK68698 ; MAV_2884 .
GeneIDi 4527187.
KEGGi mav:MAV_2884.
PATRICi 17987461. VBIMycAvi38287_2817.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci MAVI243243:GH3Y-2884-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiGCSP_MYCA1
AccessioniPrimary (citable) accession number: A0QGN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi