Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0QGN2

- GCSP_MYCA1

UniProt

A0QGN2 - GCSP_MYCA1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-2884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:MAV_2884
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Glycine dehydrogenase (decarboxylating)PRO_1000045589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei692 – 6921N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi243243.MAV_2884.

Structurei

3D structure databases

ProteinModelPortaliA0QGN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QGN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDHTTFAAR HIGPDPQAVA AMLDVIGVGS LDELAAKAVP AGIRDRLSAD
60 70 80 90 100
GIAPGLDRLP PPASETEALA ELRGLAEANT VAVSMIGQGY YDTLTPPVLL
110 120 130 140 150
RNILENPAWY TAYTPYQPEI SQGRLEALLN FQTMVADLTG LEIANASMLD
160 170 180 190 200
EGTAAAEAMT LMHRASRGKS NRLAVDVDVF AQTAAIVATR ARPLGIEIVT
210 220 230 240 250
ADLRDGLPDG DFFGVIAQLP GASGAITDWA ALVAQAHERG ALVALGADLL
260 270 280 290 300
ALTLITPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH ANHARQLPGR
310 320 330 340 350
LVGVSLDADG SPAYRLALQT REQHIRRDKA TSNICTAQVL LAVMAAMYAS
360 370 380 390 400
YHGAEGLTAI ARRVHGHAEA IAAALGTAVV HDRYFDTVLA RVPGRAHEVI
410 420 430 440 450
AAAKARGINL WRVDDDHVSV ACDEATTDEH VAAVLEAFGV APAEPVASEI
460 470 480 490 500
ATRTSEFLTH PAFTQYRTET AMMRYLRTLA DKDIALDRSM IPLGSCTMKL
510 520 530 540 550
NAAAEMEPIT WPEFARQHPF APASDTPGLR RLIGDLENWL VAITGYDAVS
560 570 580 590 600
LQPNAGSQGE YAGLLAIHDY HASRGEPHRD ICLIPSSAHG TNAASAALAG
610 620 630 640 650
MRVVVVGCHD NGDVDLDDLR AKVTDHRDRL STLMITYPST HGVYEHDIAE
660 670 680 690 700
ICAAVHDAGG QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG
710 720 730 740 750
GGPGVGPVAV RSHLAPFLPG HPHAPELPQG HPVSSAPYGS ASILPISWAY
760 770 780 790 800
IRMMGADGLR AASLTAITSA NYIARRLDEY FPVLYTGENG MVAHECILDL
810 820 830 840 850
RPITKATGVT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP TESETLTEVD
860 870 880 890 900
AFCDAMIAIR GEIDRVGAGE WPVEDNPLRG APHTAECLVT TDWDHPYSRE
910 920 930 940
QAAYPLGKDF RPKVWPPVRR IDGAYGDRNL VCSCPPVEAF A
Length:941
Mass (Da):99,961
Last modified:January 9, 2007 - v1
Checksum:iD8668C4BC2C65BCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK68698.1.
RefSeqiWP_011725113.1. NC_008595.1.
YP_882070.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK68698; ABK68698; MAV_2884.
GeneIDi4527187.
KEGGimav:MAV_2884.
PATRICi17987461. VBIMycAvi38287_2817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK68698.1 .
RefSeqi WP_011725113.1. NC_008595.1.
YP_882070.1. NC_008595.1.

3D structure databases

ProteinModelPortali A0QGN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243243.MAV_2884.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK68698 ; ABK68698 ; MAV_2884 .
GeneIDi 4527187.
KEGGi mav:MAV_2884.
PATRICi 17987461. VBIMycAvi38287_2817.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci MAVI243243:GH3Y-2884-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiGCSP_MYCA1
AccessioniPrimary (citable) accession number: A0QGN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3