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A0QGL9 (A0QGL9_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL ABK66058.1
Ordered Locus Names:MAV_2871
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding26 – 316NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding49 – 513NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding91 – 933NADP By similarity PIRSR PIRSR000109-3
Region145 – 1473Substrate binding By similarity PIRSR PIRSR000109-2
Region202 – 2032Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1991Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2061Proton donor By similarity PIRSR PIRSR000109-1
Binding site1191NADP By similarity PIRSR PIRSR000109-3
Binding site1191Substrate By similarity PIRSR PIRSR000109-2
Binding site2071Substrate By similarity PIRSR PIRSR000109-2
Binding site2771Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site3041Substrate By similarity PIRSR PIRSR000109-2
Binding site4621Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4681Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A0QGL9 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: D83FF1A3AD4D98A5

FASTA49453,342
        10         20         30         40         50         60 
MRGEDMSSSV TPSRPTTGTA QIGVTGLAVM GSNIARNFAR HGYTVALHNR SIAKTDALLK 

        70         80         90        100        110        120 
EHGDEGEFVR CETIAEFLDA LEKPRRVLIM VKAGDPTDAV INELADAMEP GDIIIDGGNA 

       130        140        150        160        170        180 
LYTDTIRREQ AMRERGLHFV GAGISGGEEG ALNGPSIMPG GPAESYRSLG PLLEEISAHV 

       190        200        210        220        230        240 
DGVPCCTHIG PDGAGHFVKM VHNGIEYSDM QLIGEAYQLL RDALGKTAEQ IADVFDEWNS 

       250        260        270        280        290        300 
GDLDSFLVEI TAQVLRQTDA KTGKPLVDLI LDEAEQKGTG RWTVKSALDL GVPVTGIAEA 

       310        320        330        340        350        360 
VFARALSGSV AQRRATTGLA SGRLGEKPSD AAQFTEDIRQ ALYASKIIAY AQGFNQIQAG 

       370        380        390        400        410        420 
SAEYGWDITP GDLATIWRGG CIIRAKFLNR IKDAFDENPD LPTLIVAPYF RSAIEAAIDG 

       430        440        450        460        470        480 
WRRVVVTATR LGIPIPGFSS ALSYYDALRT ERLPAALTQG LRDFFGAHTY GRIDEDPDKR 

       490 
FHTLWSADRR EVPA

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK66058.1.
RefSeqYP_882057.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QGL9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QGL9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000011037; EBMYCP00000010923; EBMYCG00000011035.
GeneID4527752.
GenomeReviewsGene locus MAV_2871 in contig CP000479_GR.
KEGGmav:MAV_2871.
PATRIC17987435. VBIMycAvi38287_2804.
TIGRMAV_2871.

Phylogenomic databases

eggNOGCOG0362.
GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA0QGL9.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0QGL9_MYCA1
AccessionPrimary (citable) accession number: A0QGL9
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info