Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0QGK1 (UPPP_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:MAV_2853
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290728

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane284 – 30421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0QGK1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: FEB6C4FB580DC003

FASTA30532,570
        10         20         30         40         50         60 
MTAQLSYVEA VVVGAFQGVT ELFPVSSLGH AVLVPALVGG RWAQDLSVSA HRSPYLAFIV 

        70         80         90        100        110        120 
GLHVATAAAL LVFFWRDWVR ILAGFFSSLR HRRIRTPDER LAWLIVVGTI PVGLAGLALE 

       130        140        150        160        170        180 
QLFRTTLGKP VPAAAFLLLN SVALYAGEVL RRRVAPVADE PAVPDAEQQH GDEASDNRLA 

       190        200        210        220        230        240 
QLPLRRGVLI GAAQILALLP GISRSGITIV AGLWRGLSHE DAARFSFLLA TPIILAAGVY 

       250        260        270        280        290        300 
KIPELFGPLG AGIGGQVLAG SIASFVCAYL AVRYLTRYFQ TRTLTPFAIY CAVAGGASLV 


WLALR 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000479 Genomic DNA. Translation: ABK67949.1.
RefSeqYP_882039.1. NC_008595.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243243.MAV_2853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK67949; ABK67949; MAV_2853.
GeneID4530458.
KEGGmav:MAV_2853.
PATRIC17987399. VBIMycAvi38287_2786.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWEFLATG.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-2853-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_MYCA1
AccessionPrimary (citable) accession number: A0QGK1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families