A0QGK1 (UPPP_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	MAV_2853

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) › Mycobacterium avium

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290728
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential
	Transmembrane	284 – 304	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A0QGK1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: FEB6C4FB580DC003	FASTA	305	32,570
	10 20 30 40 50 60 MTAQLSYVEA VVVGAFQGVT ELFPVSSLGH AVLVPALVGG RWAQDLSVSA HRSPYLAFIV 70 80 90 100 110 120 GLHVATAAAL LVFFWRDWVR ILAGFFSSLR HRRIRTPDER LAWLIVVGTI PVGLAGLALE 130 140 150 160 170 180 QLFRTTLGKP VPAAAFLLLN SVALYAGEVL RRRVAPVADE PAVPDAEQQH GDEASDNRLA 190 200 210 220 230 240 QLPLRRGVLI GAAQILALLP GISRSGITIV AGLWRGLSHE DAARFSFLLA TPIILAAGVY 250 260 270 280 290 300 KIPELFGPLG AGIGGQVLAG SIASFVCAYL AVRYLTRYFQ TRTLTPFAIY CAVAGGASLV WLALR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK67949.1.
RefSeq	YP_882039.1. NC_008595.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	243243.MAV_2853.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK67949; ABK67949; MAV_2853.
GeneID	4530458.
KEGG	mav:MAV_2853.
PATRIC	17987399. VBIMycAvi38287_2786.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HMMWALI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	MAVI243243:GH3Y-2869-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_MYCA1

Accession

Primary (citable) accession number: A0QGK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program