A0QGI9 (AHPD_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	MAV_2840

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359496
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QGI9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 53913FDFE05AE9D3	FASTA	178	18,872
	10 20 30 40 50 60 MSVENLKEAL PEYAKDLKLN LGSITRTTEL NEEQLWGTLL ASAAATRNTQ VLTEIGAEAA 70 80 90 100 110 120 DTLSAEAYHA ALGAASVMAM NNVFYRGRGF LDGKYDDLRA GLRMNIIGNP GVEKANFELW 130 140 150 160 170 CFAVSAINGC PDCVASHEHT LREAGVSRET IQEALKAAAI ISGVAQAIVT SQTLATAG

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK67457.1.
RefSeq	YP_882027.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QGI9.
SMR	A0QGI9. Positions 2-175.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QGI9.
Protein family/group databases
PeroxiBase	4581. MavAhpD_104.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000011126; EBMYCP00000011012; EBMYCG00000011124.
GeneID	4527294.
GenomeReviews	Gene locus MAV_2840 in contig CP000479_GR.
KEGG	mav:MAV_2840.
PATRIC	17987373. VBIMycAvi38287_2773.
TIGR	MAV_2840.
Phylogenomic databases
eggNOG	COG2128.
GeneTree	EBGT00050000016698.
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK791846.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_2840-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_MYCA1

Accession

Primary (citable) accession number: A0QGI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program