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A0QDI4 (A0QDI4_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412 EMBL ABK68578.1
Ordered Locus Names:MAV_1747
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Sequences

Sequence LengthMass (Da)Tools
A0QDI4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 6B76B0C1A059B448

FASTA43545,555
        10         20         30         40         50         60 
MGLQAPFRSG GGTSRPQGRA APRAVDLRRE VHDAARRARV ASRVLALLPT VAKDQALRSA 

        70         80         90        100        110        120 
ADAIAGHAEL ILSANAEDLE TARAAGTPSA MLDRLALDTK RVEGIAAGLR QVAGLPDPVG 

       130        140        150        160        170        180 
EVLRGYTLPN GLQLRQQRVP LGVVGMIYEG RPNVTVDAFG LALKSGNAVL LRGSSSATRS 

       190        200        210        220        230        240 
NQALVQVLRA SLVSEDLPAD AVQLLSADDR ATVTHLIQAR GLVDVVIPRG GANLINAVVR 

       250        260        270        280        290        300 
DAQVPTIETG VGNCHVYVHE GADLEVAERV LLNSKTRRPS VCNAAETLLV DAAIAEEALP 

       310        320        330        340        350        360 
RLVTALQDAG VTVHGGFARD ATEDDLRREY LSMDIAVAVV DGVDAAIAHI NEYGTGHTEA 

       370        380        390        400        410        420 
IVTTNMAAAQ RFTDGVDAAA VMVNASTAFT DGEQFGFGAE IGISTQKLHA RGPMGLPELT 

       430 
STKWIAWGDG QTRPA

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK68578.1.
RefSeqYP_880972.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QDI4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QDI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000009313; EBMYCP00000009199; EBMYCG00000009311.
GeneID4526195.
GenomeReviewsGene locus MAV_1747 in contig CP000479_GR.
KEGGmav:MAV_1747.
PATRIC17985220. VBIMycAvi38287_1701.
TIGRMAV_1747.

Phylogenomic databases

eggNOGCOG0014.
GeneTreeEBGT00050000015663.
HOGENOMHBG318080.
OMAQYPAACN.
PhylomeDBA0QDI4.
ProtClustDBPRK00197.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0QDI4_MYCA1
AccessionPrimary (citable) accession number: A0QDI4
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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