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A0QCW2 (A0QCW2_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384
Gene names
Name:thrB HAMAP MF_00384 EMBL ABK64817.1
Ordered Locus Names:MAV_1511
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384 SAAS SAAS006203

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384 SAAS SAAS006203

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP MF_00384 SAAS SAAS006203.

Sequence similarities

Belongs to the GHMP kinase family. RuleBase RU004209

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding92 – 10211ATP By similarity HAMAP MF_00384

Sequences

Sequence LengthMass (Da)Tools
A0QCW2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: CD4D7BE39F235540

FASTA31131,887
        10         20         30         40         50         60 
MLPAGLVASA VVSASSANLG PGFDSIGLAL SLIDEITVET TDSGLVVQVE GEGADQVPLG 

        70         80         90        100        110        120 
PEHLVVRAVE CGLRAVGVRA AGLVVRCRNA IPHSRGLGSS AAAVVGGLAA ANGLVAQANC 

       130        140        150        160        170        180 
QPLSDAALIQ LSSEFEGHPD NAAAAVFGGA IVSWIDRGGQ HPRYAAAPLR LHPDIHLYCA 

       190        200        210        220        230        240 
IPQERSLTAE TRVLLPAQVS HEDARFNVSR AALLVVALTE RPDLLMAATE DVLHQPQRAP 

       250        260        270        280        290        300 
AMPASAEYLR LLRRHNVAAT LSGAGPSLIA LTTASALPPE VTEYGAANGF TLAEMTAGQG 

       310 
VRWSPGVTVV G

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK64817.1.
RefSeqYP_880750.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QCW2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QCW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000009655; EBMYCP00000009541; EBMYCG00000009653.
GeneID4526435.
GenomeReviewsGene locus MAV_1511 in contig CP000479_GR.
KEGGmav:MAV_1511.
PATRIC17984751. VBIMycAvi38287_1476.
TIGRMAV_1511.

Phylogenomic databases

eggNOGCOG0083.
GeneTreeEBGT00050000016145.
HOGENOMHBG646290.
OMADRLHQPY.
PhylomeDBA0QCW2.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0QCW2_MYCA1
AccessionPrimary (citable) accession number: A0QCW2
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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