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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Mycobacterium avium (strain 104)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131ZincUniRule annotation
Metal bindingi16 – 161ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-1310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:MAV_1310
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000001574 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3003001D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylasePRO_0000400193Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0QCB7.
SMRiA0QCB7. Positions 1-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241173.
KOiK15525.
OMAiCAGDEAD.
OrthoDBiEOG6NSGK1.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

A0QCB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETPRLLFV HAHPDDESLG TGATIAHYTA AGADVRVVTC TLGEEGEVIG
60 70 80 90 100
ERWAELAVDR ADQLGGYRIG ELTAALRELG VGEPCYLGGA GRWRDSGMPG
110 120 130 140 150
TPKRRRQRFI DADEREAVGA LVAVIREQRP HVVVGYDPAG GYGHPDHVHV
160 170 180 190 200
HTVTTAAVAA AGAGDFPGEP WAVPKFYWSV FATRPFEAAV QALTPEDLRP
210 220 230 240 250
DWSMPSAEQF TFGYADDHID AVVAAGPHAW AAKRAALAAH ATQVVVGPTG
260 270 280 290 300
RACALSNNVA LPILDEEHYV LVAGAAGARD ERGWETDLLA GLEFGAAPRR
Length:300
Mass (Da):31,911
Last modified:January 9, 2007 - v1
Checksum:i87B5D9FA1EA11A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67372.1.
RefSeqiWP_009975503.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK67372; ABK67372; MAV_1310.
KEGGimav:MAV_1310.
PATRICi17984363. VBIMycAvi38287_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK67372.1.
RefSeqiWP_009975503.1. NC_008595.1.

3D structure databases

ProteinModelPortaliA0QCB7.
SMRiA0QCB7. Positions 1-297.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK67372; ABK67372; MAV_1310.
KEGGimav:MAV_1310.
PATRICi17984363. VBIMycAvi38287_1283.

Phylogenomic databases

HOGENOMiHOG000241173.
KOiK15525.
OMAiCAGDEAD.
OrthoDBiEOG6NSGK1.

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-1310-MONOMER.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiMSHB_MYCA1
AccessioniPrimary (citable) accession number: A0QCB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: January 9, 2007
Last modified: November 11, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.