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A0QC38 (A0QC38_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191 EMBL ABK66594.1
Ordered Locus Names:MAV_1230
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A0QC38 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 01E6215B7EB69859

FASTA29632,013
        10         20         30         40         50         60 
MDRAVETVER ALEKHGPPVY VRHEIVHNRH VVSTLEKAGA VFVEETDEVP EGAIVVFSAH 

        70         80         90        100        110        120 
GVAPTVHAAA AERNLHTIDA TCPLVTKVHN EARRFARNDY DILLIGHEGH EEVVGTAGEA 

       130        140        150        160        170        180 
PDHVQLVDGV AAVDNVTVRD EDKVVWLSQT TLSVDETMEI VERLRQRFPK LQDPPSDDIC 

       190        200        210        220        230        240 
YATQNRQVAV KAMAPECDLV IVVGSRNSSN SVRLVEVALG GGAGAAHLVD WADDIDPAWL 

       250        260        270        280        290 
EGVTTVGVTS GASVPEVLVQ GVLERLAECG FDVVQPVTTA QETLVFALPR EIRSAR

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK66594.1.
RefSeqYP_880476.1. NC_008595.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0QC38.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000011715; EBMYCP00000011601; EBMYCG00000011713.
GeneID4530804.
GenomeReviewsGene locus MAV_1230 in contig CP000479_GR.
KEGGmav:MAV_1230.
PATRIC17984203. VBIMycAvi38287_1203.
TIGRMAV_1230.

Phylogenomic databases

eggNOGCOG0761.
GeneTreeEBGT00050000016858.
HOGENOMHBG335228.
OMAAMAPECD.
PhylomeDBA0QC38.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0QC38_MYCA1
AccessionPrimary (citable) accession number: A0QC38
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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