A0QBW3 (PTH_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	MAV_1151

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_1000010611

Sequences

	Sequence		Length	Mass (Da)
	A0QBW3 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: E971D826B0AFDAAF	FASTA	191	20,553
	10 20 30 40 50 60 MAEPLLVVGL GNPGDNYART RHNVGFMVAD LLAARMGSKF KAHKRSGAEI VSGRLAGRSV 70 80 90 100 110 120 VVAKPRCYMN ESGRQVGPLA KFYSVPPGDI IVIHDDLDLD FGRIRLKIGG GEGGHNGLRS 130 140 150 160 170 180 VSNALGSKDF QRVRIGIGRP PGRKDPAAFV LENFTSTERA DVPTICEQAA DATELLIELG 190 LEPAQNRVHA W

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK67555.1.
RefSeq	YP_880401.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QBW3.
SMR	A0QBW3. Positions 1-191.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QBW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000011049; EBMYCP00000010935; EBMYCG00000011047.
GeneID	4529232.
GenomeReviews	Gene locus MAV_1151 in contig CP000479_GR.
KEGG	mav:MAV_1151.
PATRIC	17984040. VBIMycAvi38287_1124.
TIGR	MAV_1151.
Phylogenomic databases
eggNOG	COG0193.
GeneTree	EBGT00050000017462.
HOGENOM	HBG610927.
OMA	IKFKTGG.
PhylomeDB	A0QBW3.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	MAVI243243:MAV_1151-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_MYCA1

Accession

Primary (citable) accession number: A0QBW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program