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A0QBQ9 (MPRA_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene names
Name:mprA
Ordered Locus Names:MAV_1094
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated and dephosphorylated by MprB By similarity.

Sequence similarities

Contains 1 response regulatory domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Response regulator MprA
PRO_0000308418

Regions

Domain2 – 116115Response regulatory

Amino acid modifications

Modified residue4614-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QBQ9 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 57BB467F9F3EB339

FASTA22825,681
        10         20         30         40         50         60 
MRILVVDDDR AVRESLRRSL SFNGYSVELA HDGVEALDMI ASDRPDALVL DVMMPRLDGL 

        70         80         90        100        110        120 
EVCRQLRSTG DDLPILVLTA RDSVSERVAG LDAGADDYLP KPFALEELLA RMRALLRRTK 

       130        140        150        160        170        180 
PEDDAESVAM TFSDLTLDPV TREVTRGQRR ISLTRTEFAL LEMLIANPRR VLTRSRILEE 

       190        200        210        220 
VWGFDFPTSG NALEVYVGYL RRKTEADGEP RLIHTVRGVG YVLRETPP 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000479 Genomic DNA. Translation: ABK66309.1.
RefSeqYP_880347.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QBQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243243.MAV_1094.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK66309; ABK66309; MAV_1094.
GeneID4526296.
KEGGmav:MAV_1094.
PATRIC17983923. VBIMycAvi38287_1067.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034815.
KOK07669.
OMADFMGDSN.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK790869.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-1094-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPRA_MYCA1
AccessionPrimary (citable) accession number: A0QBQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families