Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0QBQ9

- MPRA_MYCA1

UniProt

A0QBQ9 - MPRA_MYCA1

Protein

Response regulator MprA

Gene

mprA

Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. response to stress Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response, Transcription, Transcription regulation, Two-component regulatory system, Virulence

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMAVI243243:GH3Y-1094-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Response regulator MprA
    Alternative name(s):
    Mycobacterial persistence regulator A
    Gene namesi
    Name:mprA
    Ordered Locus Names:MAV_1094
    OrganismiMycobacterium avium (strain 104)
    Taxonomic identifieri243243 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000001574: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Response regulator MprAPRO_0000308418Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 4614-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated and dephosphorylated by MprB.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi243243.MAV_1094.

    Structurei

    3D structure databases

    ProteinModelPortaliA0QBQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 116115Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034815.
    KOiK07669.
    OMAiCKAIRSK.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0QBQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILVVDDDR AVRESLRRSL SFNGYSVELA HDGVEALDMI ASDRPDALVL    50
    DVMMPRLDGL EVCRQLRSTG DDLPILVLTA RDSVSERVAG LDAGADDYLP 100
    KPFALEELLA RMRALLRRTK PEDDAESVAM TFSDLTLDPV TREVTRGQRR 150
    ISLTRTEFAL LEMLIANPRR VLTRSRILEE VWGFDFPTSG NALEVYVGYL 200
    RRKTEADGEP RLIHTVRGVG YVLRETPP 228
    Length:228
    Mass (Da):25,681
    Last modified:January 9, 2007 - v1
    Checksum:i57BB467F9F3EB339
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK66309.1.
    RefSeqiYP_880347.1. NC_008595.1.

    Genome annotation databases

    EnsemblBacteriaiABK66309; ABK66309; MAV_1094.
    GeneIDi4526296.
    KEGGimav:MAV_1094.
    PATRICi17983923. VBIMycAvi38287_1067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000479 Genomic DNA. Translation: ABK66309.1 .
    RefSeqi YP_880347.1. NC_008595.1.

    3D structure databases

    ProteinModelPortali A0QBQ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243243.MAV_1094.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK66309 ; ABK66309 ; MAV_1094 .
    GeneIDi 4526296.
    KEGGi mav:MAV_1094.
    PATRICi 17983923. VBIMycAvi38287_1067.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034815.
    KOi K07669.
    OMAi CKAIRSK.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci MAVI243243:GH3Y-1094-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 104.

    Entry informationi

    Entry nameiMPRA_MYCA1
    AccessioniPrimary (citable) accession number: A0QBQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3