A0QBQ9 (MPRA_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Response regulator MprA

Alternative name(s):
Mycobacterial persistence regulator A

Gene names

Name:	mprA
Ordered Locus Names:	MAV_1094

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) › Mycobacterium avium

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.
Subcellular location	Cytoplasm Potential.
Post-translational modification	Phosphorylated and dephosphorylated by MprB By similarity.
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Stress response Transcription Transcription regulation Two-component regulatory system Virulence
Cellular component	Cytoplasm
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Response regulator MprA		PRO_0000308418
Regions
	Domain	2 – 116	115	Response regulatory
Amino acid modifications
	Modified residue	46	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QBQ9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 57BB467F9F3EB339	FASTA	228	25,681
	10 20 30 40 50 60 MRILVVDDDR AVRESLRRSL SFNGYSVELA HDGVEALDMI ASDRPDALVL DVMMPRLDGL 70 80 90 100 110 120 EVCRQLRSTG DDLPILVLTA RDSVSERVAG LDAGADDYLP KPFALEELLA RMRALLRRTK 130 140 150 160 170 180 PEDDAESVAM TFSDLTLDPV TREVTRGQRR ISLTRTEFAL LEMLIANPRR VLTRSRILEE 190 200 210 220 VWGFDFPTSG NALEVYVGYL RRKTEADGEP RLIHTVRGVG YVLRETPP

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK66309.1.
RefSeq	YP_880347.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QBQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	243243.MAV_1094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK66309; ABK66309; MAV_1094.
GeneID	4526296.
KEGG	mav:MAV_1094.
PATRIC	17983923. VBIMycAvi38287_1067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034815.
KO	K07669.
OMA	MLMANPR.
ProtClustDB	CLSK790869.
Enzyme and pathway databases
BioCyc	MAVI243243:GH3Y-1127-MONOMER.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPRA_MYCA1

Accession

Primary (citable) accession number: A0QBQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program