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Protein

Response regulator MprA

Gene

mprA

Organism
Mycobacterium avium (strain 104)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. phosphorelay signal transduction system Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-1094-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene namesi
Name:mprA
Ordered Locus Names:MAV_1094
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Response regulator MprAPRO_0000308418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 4614-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated and dephosphorylated by MprB.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_1094.

Structurei

3D structure databases

ProteinModelPortaliA0QBQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 116115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK07669.
OMAiFTLLEMF.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0QBQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRILVVDDDR AVRESLRRSL SFNGYSVELA HDGVEALDMI ASDRPDALVL
60 70 80 90 100
DVMMPRLDGL EVCRQLRSTG DDLPILVLTA RDSVSERVAG LDAGADDYLP
110 120 130 140 150
KPFALEELLA RMRALLRRTK PEDDAESVAM TFSDLTLDPV TREVTRGQRR
160 170 180 190 200
ISLTRTEFAL LEMLIANPRR VLTRSRILEE VWGFDFPTSG NALEVYVGYL
210 220
RRKTEADGEP RLIHTVRGVG YVLRETPP
Length:228
Mass (Da):25,681
Last modified:January 9, 2007 - v1
Checksum:i57BB467F9F3EB339
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK66309.1.
RefSeqiYP_880347.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK66309; ABK66309; MAV_1094.
GeneIDi4526296.
KEGGimav:MAV_1094.
PATRICi17983923. VBIMycAvi38287_1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA. Translation: ABK66309.1.
RefSeqiYP_880347.1. NC_008595.1.

3D structure databases

ProteinModelPortaliA0QBQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243243.MAV_1094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK66309; ABK66309; MAV_1094.
GeneIDi4526296.
KEGGimav:MAV_1094.
PATRICi17983923. VBIMycAvi38287_1067.

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK07669.
OMAiFTLLEMF.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-1094-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiMPRA_MYCA1
AccessioniPrimary (citable) accession number: A0QBQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 9, 2007
Last modified: January 7, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.