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A0QBN4 (G6PI_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:MAV_1068
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000013987

Sites

Active site3581Proton donor By similarity
Active site3891 By similarity
Active site5151 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QBN4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 780F82619506EF92

FASTA55460,652
        10         20         30         40         50         60 
MTSVHTLPDI TATPAWDALR KHHDRIGDTH LRQFFEEDPD RGRELTVTVG DLYIDYSKHR 

        70         80         90        100        110        120 
VTRETLRLLV DLARTAKLEE RRDQMFAGVH INTSEDRAVL HTALRLPRDA ELIVDGRNVV 

       130        140        150        160        170        180 
ADVHEVLDAM GEFTDRLRSG EWTGATGKRI STVVNIGIGG SDLGPVMVYQ ALRHYADAGI 

       190        200        210        220        230        240 
SARFVSNVDP ADLIATLADL DPATTLFIVA SKTFSTLETL TNATAARRWI TDALGDAAVA 

       250        260        270        280        290        300 
HHFVAVSTNK RLVDDFGINT DNMFGFWDWV GGRYSVDSAI GLSVMAVIGR EAFADFLSGF 

       310        320        330        340        350        360 
HIVDRHFQTA PLESNAPVLL GLIGLWYSNF MGAQSRAVLP YSNDLARFAA YLQQLTMESN 

       370        380        390        400        410        420 
GKSTRADGSP VTTDTGEIFW GEPGTNGQHA FYQLLHQGTR LVPADFIGFS QPIDDLPTAE 

       430        440        450        460        470        480 
GSGSMHDLLM SNFFAQTQVL AFGKTAEEIA AEGTPADIVP HKVMPGNRPS TSILANRLTP 

       490        500        510        520        530        540 
SVLGQLIALY EHQVFTEGVI WGIDSFDQWG VELGKTQAKA LLPVITADNS PAPQSDSSTD 

       550 
ALVRRYRSER GRTS

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK66481.1.
RefSeqYP_880322.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QBN4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QBN4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000011561; EBMYCP00000011447; EBMYCG00000011559.
GeneID4529585.
GenomeReviewsGene locus MAV_1068 in contig CP000479_GR.
KEGGmav:MAV_1068.
PATRIC17983871. VBIMycAvi38287_1041.
TIGRMAV_1068.

Phylogenomic databases

eggNOGCOG0166.
GeneTreeEBGT00050000016991.
HOGENOMHBG352954.
OMANSLPAWT.
PhylomeDBA0QBN4.
ProtClustDBPRK00179.

Enzyme and pathway databases

BioCycMAVI243243:MAV_1068-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_MYCA1
AccessionPrimary (citable) accession number: A0QBN4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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