Reviewed, UniProtKB/Swiss-Prot A0QBE6 (KDC_MYCA1)

Names and origin

Protein names

Recommended name:
    Alpha-keto-acid decarboxylase
      Short name=KDC
    EC=4.1.1.-

Gene names

Name:	kdc
Ordered Locus Names:	MAV_0973

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.
Cofactor	Binds 1 metal ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity.
Sequence similarities	Belongs to the TPP enzyme family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding Thiamine pyrophosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	carboxy-lyase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Alpha-keto-acid decarboxylase		PRO_0000333745
Regions
	Region	394 – 476	83	Thiamine pyrophosphate binding By similarity
Sites
	Metal binding	444	1	Magnesium By similarity
	Metal binding	471	1	Magnesium By similarity
	Metal binding	473	1	Magnesium; via carbonyl oxygen By similarity
	Binding site	59	1	Thiamine pyrophosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QBE6-1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 8619B4655D5C0B13	FASTA	563	60,389
	10 20 30 40 50 60 MPVTDAATEP AYTVGDYLLD RLAELGVSEI FGVPGDYNLE FLDHIVAHPR LRWVGNANEL 70 80 90 100 110 120 NAGYAADGYG RLRGMSALVT TFGVGELSAA NAVAGSYAEQ VPVVHIVGGP SKDAQGTRRA 130 140 150 160 170 180 LHHSLGDGDF EHFFRVSREI TCAQANLMPA TARREIDRVL SEVREQKRPG YILLSTDVAR 190 200 210 220 230 240 FPTEPPEAAL PRYTGGTSPR ALAMFTEAAA ALIGEHRITV LADLLVHRLQ AIKELEALLA 250 260 270 280 290 300 ADVVPHATLM WGKSLLDESS PNFLGIYAGS ASAPAVRTAI EEAPVLVTAG VVFTDMVSGF 310 320 330 340 350 360 FSQRIDPART IDVGQYQSSV AGEVFAPLEM GEALQALAAI LTRRGVSSPP VASPPAEPLP 370 380 390 400 410 420 PPPPREQPLT QKMVWDRVCT ALTPGNVVLA DQGTSFYGMA DHRLPQGVTF IGQPLWGSIG 430 440 450 460 470 480 YTLPAALGAA VAHPDRRTVL LIGDGAAQLT VQELGTFARE GLSPVIVVVN NDGYTVERAI 490 500 510 520 530 540 HGETAPYNDI VGWKWTEVPN SLGVTDHLAF RVQTYGELDD ALTAAARHQD RMVLVEVVLP 550 560 RLEIPRLLVE LVRPTSPDGS PRR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000479 Genomic DNA. Translation: ABK66465.1. Different initiation.
RefSeq	YP_880234.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4529569.
GenomeReviews	Gene locus MAV_0973 in contig CP000479_GR.
KEGG	mav:MAV_0973.
TIGR	MAV_0973.
Family and domain databases
InterPro	IPR000399. TPP_bd_CS. IPR012001. TPP_bd_enzyme_N. IPR011766. TPP_enzyme_bd_C. IPR012000. TPP_enzyme_M. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KDC_MYCA1

Accession

Primary (citable) accession number: A0QBE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	June 16, 2009
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)