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A0QAT4 (A0QAT4_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Name:purF EMBL ABK66986.1
Ordered Locus Names:MAV_0747
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site171For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2581Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4041Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4601Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4631Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A0QAT4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 1B360CF84B6872AE

FASTA50854,282
        10         20         30         40         50         60 
MTVAEPEQDF NAPREECGVF GVWAPGEEVA KLTYYGLYAL QHRGQEAAGI AVADGSQVLV 

        70         80         90        100        110        120 
FKDLGLVSQV FDEQTLAAMQ GHVAIGHCRY STTGDTTWEN AQPVFRNTAA GTGVALGHNG 

       130        140        150        160        170        180 
NLVNTAELAA RARDAGLIAK RAPAPATTDS DILGALLAHG AADSTLEQAA LDLLPTVRGA 

       190        200        210        220        230        240 
FCLTFMDENT LYACRDPHGV RPLSLGRLDR GWVVASETAA LDIVGASFVR DIEPGELLAI 

       250        260        270        280        290        300 
DADGVRSTRF ANPTPKGCVF EYVYLARPDS TIAGRSVHAT RVEIGRRLAR ERPVEADLVI 

       310        320        330        340        350        360 
GVPESGTPAA VGYAQESGIP YGQGLMKNAY VGRTFIQPSQ TIRQLGIRLK LNPLREVIRG 

       370        380        390        400        410        420 
KRLIVVDDSI VRGNTQRALL RMLREAGAVE VHVRIASPPV KWPCFYGIDF PSPAELIANA 

       430        440        450        460        470        480 
VEDKHEMLEA VRHAIGADSL GYISLRGLIA ASEQPASRLC TACFDGQYPI ELPGETALGK 

       490        500 
NVIEHMLANA ARGAGLDDLA ADEVPVVH

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK66986.1.
RefSeqYP_880022.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QAT4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QAT4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000012341; EBMYCP00000012227; EBMYCG00000012339.
GeneID4526726.
GenomeReviewsGene locus MAV_0747 in contig CP000479_GR.
KEGGmav:MAV_0747.
PATRIC17983229. VBIMycAvi38287_0726.
TIGRMAV_0747.

Phylogenomic databases

eggNOGCOG0034.
GeneTreeEBGT00050000016850.
HOGENOMHBG392416.
OMAVWAPGEE.
PhylomeDBA0QAT4.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0QAT4_MYCA1
AccessionPrimary (citable) accession number: A0QAT4
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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