A0QAR2 (A0QAR2_MYCA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137 RuleBase RU000613
EC=6.3.2.6 HAMAP MF_00137 RuleBase RU000613

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137 EMBL ABK68581.1
Ordered Locus Names:	MAV_0725

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS018236 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 RuleBase RU000613 SAAS SAAS018236 EMBL ABK68581.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0QAR2 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 2D99EA716B534B05	FASTA	296	32,945
	10 20 30 40 50 60 MPALSDYQHL VSGKVRELYR VDDEHLLLVA TDRISAYDFV LDSTIPDKGR ILTAMSVFFF 70 80 90 100 110 120 GLVDAPNHLA GPPDDPRIPD EVLGRALVVR QLEMLPVECV ARGYLTGSGL LDYQATGKVC 130 140 150 160 170 180 GIALPPGLVE ASKFAEPLFT PATKAALGDH DENISFARVI EMVGGVRANQ LRDRTLQIYV 190 200 210 220 230 240 QAADHALRKG IIIADTKFEF GTDPDGNLLL ADEIFTPDSS RYWPADEYRV GVPQTSFDKQ 250 260 270 280 290 FVRNWLTSPE SGWDRHGTEP PPPLPDHIIE ATRNRYIEAY ERISGLRFDD WIGPRA

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK68581.1.
RefSeq	YP_880000.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QAR2.
ModBase	Search...
Protein-protein interaction databases
STRING	A0QAR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000011581; EBMYCP00000011467; EBMYCG00000011579.
GeneID	4526239.
GenomeReviews	Gene locus MAV_0725 in contig CP000479_GR.
KEGG	mav:MAV_0725.
PATRIC	17983187. VBIMycAvi38287_0705.
TIGR	MAV_0725.
Phylogenomic databases
eggNOG	COG0152.
GeneTree	EBGT00050000017539.
HOGENOM	HBG555040.
OMA	LTLMDEV.
PhylomeDB	A0QAR2.
ProtClustDB	PRK13961.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0QAR2_MYCA1

Accession

Primary (citable) accession number: A0QAR2

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)