Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0QAG8 (ACDH_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:MAV_0626
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387672

Regions

Nucleotide binding6 – 94NAD By similarity
Nucleotide binding152 – 1609NAD By similarity

Sites

Active site1211Acyl-thioester intermediate By similarity
Binding site2711NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A0QAG8 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: B0127F94E307236B

FASTA29831,687
        10         20         30         40         50         60 
MAIVGSGNIS TDLLYKLLRS DWLEPRWMVG IDPQSEGLAR ARKLGLETTH EGVDWLLAQP 

        70         80         90        100        110        120 
EKPDLVFEAT SAYVHRDAAP KYEAAGIRAI DLTPAAVGPA VIPPANLRQH LDAPNVNMIT 

       130        140        150        160        170        180 
CGGQATIPIV YAVSRVVEVP YAEIVASVAS VSAGPGTRAN IDEFTKTTSR GVETIGGAKR 

       190        200        210        220        230        240 
GKAIIILNPA DPPMIMRDTI FCAIPEDADR DAIAQSIHDV VKEVQSYVPG YRLLNEPQFD 

       250        260        270        280        290 
DPSLNSGGQA LVTTFVEVEG AGDYLPPYAG NLDIMTAAAT KVGEEIAKET LSVAGGTR 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000479 Genomic DNA. Translation: ABK65233.1.
RefSeqYP_879906.2. NC_008595.1.

3D structure databases

ProteinModelPortalA0QAG8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243243.MAV_0626.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK65233; ABK65233; MAV_0626.
GeneID4528328.
KEGGmav:MAV_0626.
PATRIC17982988. VBIMycAvi38287_0607.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMADIQQYVP.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-626-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_MYCA1
AccessionPrimary (citable) accession number: A0QAG8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families