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A0QAB3 (A0QAB3_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108 RuleBase RU003490
EC=2.7.7.60 HAMAP MF_00108 RuleBase RU003490
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108
Gene names
Name:ispD HAMAP MF_00108 EMBL ABK66925.1
Ordered Locus Names:MAV_0571
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 RuleBase RU003490 SAAS SAAS018294

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 RuleBase RU003490 SAAS SAAS018294

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004138

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108 RuleBase RU004393

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site231Transition state stabilizer By similarity HAMAP MF_00108
Site301Transition state stabilizer By similarity HAMAP MF_00108
Site1581Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2131Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A0QAB3 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 52450D2C99D08879

FASTA22923,159
        10         20         30         40         50         60 
MAPETGSSGA VAAVVPAAGS GERLAAGIPK AFCEIDGASM LARAVAGLLD SKVVDHVVVA 

        70         80         90        100        110        120 
VPADRVDEAK RLLAAQATVV AGGADRTASV RLALAAVPGN PAFVLVHDAA RALTPPALIA 

       130        140        150        160        170        180 
RVVQALRDGH RAVVPALPLH DTVKAVDANG VVLGTPERDG LRAVQTPQGF ATDLLLRAYA 

       190        200        210        220 
AGAGTAGFTD DASLVEHVGG QVQVVDGDPL AFKITTQLDL LLAETIVRR

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK66925.1.
RefSeqYP_879851.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0QAB3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0QAB3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000009343; EBMYCP00000009229; EBMYCG00000009341.
GeneID4529428.
GenomeReviewsGene locus MAV_0571 in contig CP000479_GR.
KEGGmav:MAV_0571.
PATRIC17982880. VBIMycAvi38287_0553.
TIGRMAV_0571.

Phylogenomic databases

eggNOGCOG1211.
GeneTreeEBGT00050000016717.
HOGENOMHBG672839.
OMASKVIVVC.
ProtClustDBPRK00155.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0QAB3_MYCA1
AccessionPrimary (citable) accession number: A0QAB3
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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