A0QA93 (PANC_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate synthetase
Short name=PS
EC=6.3.2.1

Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	MAV_0551

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) › Mycobacterium avium

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00158.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP-Rule MF_00158
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Pantothenate synthetase HAMAP-Rule MF_00158		PRO_0000305485
Regions
	Nucleotide binding	39 – 46	8	ATP By similarity
	Nucleotide binding	157 – 160	4	ATP By similarity
	Nucleotide binding	194 – 197	4	ATP By similarity
Sites
	Active site	46	1	Proton donor By similarity
	Binding site	71	1	Beta-alanine By similarity
	Binding site	71	1	Pantoate By similarity
	Binding site	163	1	Pantoate By similarity
	Binding site	186	1	ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0QA93 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 951D38A77E023859	FASTA	308	32,767
	10 20 30 40 50 60 MKPAFTAGEL NTYTSPGDVT AVSRALRHTG RRVMLVPTMG ALHDGHLALV RAAKRVPGSV 70 80 90 100 110 120 VVVSIFVNPL QFSAGEDLDA YPRTLDDDLA LLRSEGVEIA FTPTAAAMYP NGLRTTVQPG 130 140 150 160 170 180 PLAAELEGGP RPTHFAGVLT VVCKLLQIVR PDRIFFGEKD YQQLVMIRQM VADLNIDVQV 190 200 210 220 230 240 VGVPTVREAD GLAMSSRNRY LDATQRELAV TLSAALTAGA HAAHLGGAAA LRAARAVLDA 250 260 270 280 290 300 VPELTVDYLE LRDAGLGPAP AHGSARLLVA ARLGNTRLLD NIEMQIETPA GTAGPDGDRQ YAQSPWRN

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK64754.1.
RefSeq	YP_879831.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0QA93.
SMR	A0QA93. Positions 3-288.
ModBase	Search...
Protein-protein interaction databases
STRING	243243.MAV_0551.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK64754; ABK64754; MAV_0551.
GeneID	4528629.
KEGG	mav:MAV_0551.
PATRIC	17982838. VBIMycAvi38287_0532.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0414.
HOGENOM	HOG000175516.
KO	K01918.
OMA	EDFGSYP.
ProtClustDB	PRK00380.
Enzyme and pathway databases
BioCyc	MAVI243243:GH3Y-590-MONOMER.
UniPathway	UPA00028; UER00005.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00158. PanC.
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_MYCA1

Accession

Primary (citable) accession number: A0QA93

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program