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A0Q8W7

- SYL_MYCA1

UniProt

A0Q8W7 - SYL_MYCA1

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Protein

Leucine--tRNA ligase

Gene
leuS, MAV_0055
Organism
Mycobacterium avium (strain 104)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei740 – 7401ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAVI243243:GH3Y-55-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MAV_0055
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000001574: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Leucine--tRNA ligaseUniRule annotationPRO_0000334773Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243243.MAV_0055.

Structurei

3D structure databases

ProteinModelPortaliA0Q8W7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi78 – 8912"HIGH" regionUniRule annotationAdd
BLAST
Motifi737 – 7415"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q8W7-1 [UniParc]FASTAAdd to Basket

« Hide

MTESPTTSPA TGSGAAAPDS DAPPYRYTAA LAGRIEGSWQ DTWAKLGTFN    50
VPNPVGSLAP TDGTPVPEDK LFVQDMFPYP SGEGLHVGHP LGYIATDVYA 100
RYFRMTGRNV LHALGFDAFG LPAEQYAVQT GTHPRTRTEA NVVNFRRQLG 150
RLGLGHDSRR SFSTTDVEFY KWTQWIFLQI YNAWFDPAAN KARPIAELVA 200
EFDSGARSLD DGRNWSELSA GERADVIDSH RLVYRADSMV NWCPGLGTVL 250
ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYSDRLLDD LDLLDWPEPV 300
KTMQRNWIGR STGAKALFAA TGADGAALDI EVFTTRPDTL FGATYMVLAP 350
EHELVDELVA PAWPDGTDPR WTYGAATPGE AVAAYRRAIA SKSDLERQES 400
KAKTGVFLGS YATNPTNGKP VPIFIADYVL AGYGTGAIMA VPGHDQRDWD 450
FAHEFGLPIV EVIAGGDISE GAYAGDGLLV NSGYLDGLDV AAAKEAITAR 500
LEAEGRGCAR VEFKLRDWLF ARQRYWGEPF PIVYDSDGRP HALDEAALPV 550
ELPDVPDYSP VLFDPDDADS EPSPPLAKAT DWVHVELDLG DGLKPYSRDT 600
NVMPQWAGSS WYELRYTDPH NSERFCAKEN EAYWMGPRPA EHGPQDPGGV 650
DLYVGGAEHA VLHLLYARFW HKVLYDLGHV SSREPYRRLV NQGYIQAFAY 700
TDSRGSYVPA EEVVERDGRF FYRGPDGEIE VFQEFGKIGK SLKNSISPDE 750
ICDDYGADTL RVYEMSMGPL EASRPWATKD VVGAHRFLQR VWRLVVDEQT 800
GETRVVDGAG RDLPTGTLRL LHRTIAGVSE DYAGLRNNTA VAKLIEYTNH 850
LTKEHRDAVP RAAVEPLVLM LAPLAPHMAE ELWLRLGHTT SLAHGPFPVA 900
DPAYLVEDTV EYPVQVNGKV RGRVTVAADA DRDTLEAAAL ADEKVLAFLA 950
GAQPRKVIVV PGRLVNLVV 969
Length:969
Mass (Da):106,886
Last modified:May 20, 2008 - v2
Checksum:i1EE8B551CF991D7D
GO

Sequence cautioni

The sequence ABK69297.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK69297.1. Different initiation.
RefSeqiYP_879355.1. NC_008595.1.

Genome annotation databases

EnsemblBacteriaiABK69297; ABK69297; MAV_0055.
GeneIDi4526376.
KEGGimav:MAV_0055.
PATRICi17981855. VBIMycAvi38287_0050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000479 Genomic DNA. Translation: ABK69297.1 . Different initiation.
RefSeqi YP_879355.1. NC_008595.1.

3D structure databases

ProteinModelPortali A0Q8W7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243243.MAV_0055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK69297 ; ABK69297 ; MAV_0055 .
GeneIDi 4526376.
KEGGi mav:MAV_0055.
PATRICi 17981855. VBIMycAvi38287_0050.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MAVI243243:GH3Y-55-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 104.

Entry informationi

Entry nameiSYL_MYCA1
AccessioniPrimary (citable) accession number: A0Q8W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi