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A0Q8W7 (SYL_MYCA1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:MAV_0055
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length969 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence ABK69297.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 969969Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334773

Regions

Motif78 – 8912"HIGH" region HAMAP-Rule MF_00049
Motif737 – 7415"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7401ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0Q8W7 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 1EE8B551CF991D7D

FASTA969106,886
        10         20         30         40         50         60 
MTESPTTSPA TGSGAAAPDS DAPPYRYTAA LAGRIEGSWQ DTWAKLGTFN VPNPVGSLAP 

        70         80         90        100        110        120 
TDGTPVPEDK LFVQDMFPYP SGEGLHVGHP LGYIATDVYA RYFRMTGRNV LHALGFDAFG 

       130        140        150        160        170        180 
LPAEQYAVQT GTHPRTRTEA NVVNFRRQLG RLGLGHDSRR SFSTTDVEFY KWTQWIFLQI 

       190        200        210        220        230        240 
YNAWFDPAAN KARPIAELVA EFDSGARSLD DGRNWSELSA GERADVIDSH RLVYRADSMV 

       250        260        270        280        290        300 
NWCPGLGTVL ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYSDRLLDD LDLLDWPEPV 

       310        320        330        340        350        360 
KTMQRNWIGR STGAKALFAA TGADGAALDI EVFTTRPDTL FGATYMVLAP EHELVDELVA 

       370        380        390        400        410        420 
PAWPDGTDPR WTYGAATPGE AVAAYRRAIA SKSDLERQES KAKTGVFLGS YATNPTNGKP 

       430        440        450        460        470        480 
VPIFIADYVL AGYGTGAIMA VPGHDQRDWD FAHEFGLPIV EVIAGGDISE GAYAGDGLLV 

       490        500        510        520        530        540 
NSGYLDGLDV AAAKEAITAR LEAEGRGCAR VEFKLRDWLF ARQRYWGEPF PIVYDSDGRP 

       550        560        570        580        590        600 
HALDEAALPV ELPDVPDYSP VLFDPDDADS EPSPPLAKAT DWVHVELDLG DGLKPYSRDT 

       610        620        630        640        650        660 
NVMPQWAGSS WYELRYTDPH NSERFCAKEN EAYWMGPRPA EHGPQDPGGV DLYVGGAEHA 

       670        680        690        700        710        720 
VLHLLYARFW HKVLYDLGHV SSREPYRRLV NQGYIQAFAY TDSRGSYVPA EEVVERDGRF 

       730        740        750        760        770        780 
FYRGPDGEIE VFQEFGKIGK SLKNSISPDE ICDDYGADTL RVYEMSMGPL EASRPWATKD 

       790        800        810        820        830        840 
VVGAHRFLQR VWRLVVDEQT GETRVVDGAG RDLPTGTLRL LHRTIAGVSE DYAGLRNNTA 

       850        860        870        880        890        900 
VAKLIEYTNH LTKEHRDAVP RAAVEPLVLM LAPLAPHMAE ELWLRLGHTT SLAHGPFPVA 

       910        920        930        940        950        960 
DPAYLVEDTV EYPVQVNGKV RGRVTVAADA DRDTLEAAAL ADEKVLAFLA GAQPRKVIVV 


PGRLVNLVV 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000479 Genomic DNA. Translation: ABK69297.1. Different initiation.
RefSeqYP_879355.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0Q8W7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243243.MAV_0055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK69297; ABK69297; MAV_0055.
GeneID4526376.
KEGGmav:MAV_0055.
PATRIC17981855. VBIMycAvi38287_0050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycMAVI243243:GH3Y-55-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_MYCA1
AccessionPrimary (citable) accession number: A0Q8W7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries