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A0Q8S1 (A0Q8S1_MYCA1) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL ABK64957.1
Ordered Locus Names:MAV_0006
OrganismMycobacterium avium (strain 104) [Complete proteome] [HAMAP]
Taxonomic identifier243243 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length839 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
A0Q8S1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: E0432A0A37E5A408

FASTA83992,340
        10         20         30         40         50         60 
MTDTTLPPGG DAADRVEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM 

        70         80         90        100        110        120 
YDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP 

       130        140        150        160        170        180 
GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG 

       190        200        210        220        230        240 
GIAVGMATNI PPHNLGELAE AVFWALDNYE ADEEATLAAV MERVKGPDFP TSGLIVGTQG 

       250        260        270        280        290        300 
IADAYKTGRG SIRMRGVVEV EEDSRGRTSL VITELPYQVN HDNFITSIAE QVRDGKLAGI 

       310        320        330        340        350        360 
SNIEDQSSDR VGLRIVIELK RDAVAKVVLN NLYKHTQLQT SFGANMLAIV DGVPRTLRLD 

       370        380        390        400        410        420 
QLIRHYVDHQ LDVIVRRTTY RLRKANERAH ILRGLVKALD ALDEVIALIR ASETVDIARQ 

       430        440        450        460        470        480 
GLIELLDIDE IQAQAILDMQ LRRLAALERQ RIIDDLAKIE AEIADLEDIL AKPERQRGIV 

       490        500        510        520        530        540 
RDELAEIVEK HGDARRTRIV AADGDVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR 

       550        560        570        580        590        600 
GGKGVQGAGL KQDDIVRHFF VCSTHDWILF FTTQGRVYRA KAYELPEASR TARGQHVANL 

       610        620        630        640        650        660 
LAFQPEERIA QVIQIRSYED APYLVLATRN GLVKKTKLTD FDSNRSGGIV AINLRDNDEL 

       670        680        690        700        710        720 
VGAVLCSAED DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD YLLSLNVVRE 

       730        740        750        760        770        780 
GTYLLVATSG GYAKRTAIEE YPVQGRGGKG VLTVMYDRRR GRLVGALIVD EDSELYAITS 

       790        800        810        820        830 
GGGVIRTAAG QVRKAGRQTK GVRLMNLGEG DTLLAIARNA EEAADEAVEE SDGAAGSDG

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References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000479 Genomic DNA. Translation: ABK64957.1.
RefSeqYP_879309.1. NC_008595.1.

3D structure databases

ProteinModelPortalA0Q8S1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0Q8S1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000012850; EBMYCP00000012736; EBMYCG00000012848.
GeneID4527270.
GenomeReviewsGene locus MAV_0006 in contig CP000479_GR.
KEGGmav:MAV_0006.
PATRIC17981761. VBIMycAvi38287_0006.
TIGRMAV_0006.

Phylogenomic databases

eggNOGCOG0188.
GeneTreeEBGT00050000016653.
HOGENOMHBG635183.
OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0Q8S1_MYCA1
AccessionPrimary (citable) accession number: A0Q8S1
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info