A0Q8R6 (A0Q8R6_MYCA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377 EMBL ABK68742.1
Ordered Locus Names:	MAV_0001

Organism

Mycobacterium avium (strain 104) [Complete proteome] [HAMAP]

Taxonomic identifier

243243 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377 RuleBase RU000577
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377 RuleBase RU004227

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377 RuleBase RU000577
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 RuleBase RU000577 DNA-binding HAMAP MF_00377 RuleBase RU000577 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	199 – 206	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	A0Q8R6 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: FA4FB4F7B2FC686B	FASTA	498	55,558
	10 20 30 40 50 60 MWNAVVSELN GEPVADGGAA NRTTLVTPLT PQQRAWLNLV RPLTIVEGFA LLSVPSSFVQ 70 80 90 100 110 120 NEIERHLRAP ITDALSRRLG QQIQLGVRIA PPPDDVEDAL IPPAEPFPDT DAALSADDGA 130 140 150 160 170 180 DGEPVENGEP VTDTQPGWPN YFTERPHAID PAVAAGTSLN RRYTFDTFVI GASNRFAHAA 190 200 210 220 230 240 ALAIAEAPAR AYNPLFIWGE SGLGKTHLLH AAGNYAQRLF PGMRVKYVST EEFTNDFINS 250 260 270 280 290 300 LRDDRKVAFK RSYRDVDVLL VDDIQFIEGK EGIQEEFFHT FNTLHNANKQ IVISSDRPPK 310 320 330 340 350 360 QLATLEDRLR TRFEWGLITD VQPPELETRI AILRKKAQME RLAVPDDVLE LIASSIERNI 370 380 390 400 410 420 RELEGALIRV TAFASLNKTP IDKSLAEIVL RDLIADASTM QISAATIMAA TAEYFDTTVE 430 440 450 460 470 480 ELRGPGKTRA LAQSRQIAMY LCRELTDLSL PKIGQAFGRD HTTVMYAQRK ILSEMAERRE 490 VFDHVKELTT RIRQRSKR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000479 Genomic DNA. Translation: ABK68742.1.
RefSeq	YP_879304.1. NC_008595.1.
3D structure databases
ProteinModelPortal	A0Q8R6.
ModBase	Search...
Protein-protein interaction databases
STRING	A0Q8R6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000012176; EBMYCP00000012062; EBMYCG00000012174.
GeneID	4529107.
GenomeReviews	Gene locus MAV_0001 in contig CP000479_GR.
KEGG	mav:MAV_0001.
PATRIC	17981751. VBIMycAvi38287_0001.
TIGR	MAV_0001.
Phylogenomic databases
eggNOG	COG0593.
GeneTree	EBGT00050000017320.
HOGENOM	HBG695666.
OMA	DEVAFLI.
PhylomeDB	A0Q8R6.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0Q8R6_MYCA1

Accession

Primary (citable) accession number: A0Q8R6

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)