ID   A0Q8J3_FRATN            Unreviewed;       448 AA.
AC   A0Q8J3;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
GN   OrderedLocusNames=FTN_1701 {ECO:0000313|EMBL:ABK90558.1};
GN   ORFNames=AW25_287 {ECO:0000313|EMBL:AJI60776.1};
OS   Francisella tularensis subsp. novicida (strain U112).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=401614 {ECO:0000313|EMBL:ABK90558.1, ECO:0000313|Proteomes:UP000000762};
RN   [1] {ECO:0000313|EMBL:ABK90558.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U112 {ECO:0000313|EMBL:ABK90558.1};
RA   Brittnacher M., Rohmer L., Zhou Y., Abmayr S., D'Argenio D., Bovee D.,
RA   Chang J., Chen J., Drees B., Ernst R., Fong C., Forsman M., Gallagher L.,
RA   Gallis B., Gillett W., Goodlett D., Guina T., Guenthner D., Haugen E.,
RA   Hayden H., Jacobs M., Kang A., Larson Freeman T., Levy R., Lim R.,
RA   Manoil C., Olson M.V., Radey M., Shaffer S., Svensson K., Taylor G.,
RA   Wasnick M., Kaul R., Miller S.I.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000000762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U112 {ECO:0000313|Proteomes:UP000000762};
RX   PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102;
RA   Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M.,
RA   Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C.,
RA   Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J.,
RA   Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A.,
RA   Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V.,
RA   Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.;
RT   "Comparison of Francisella tularensis genomes reveals evolutionary events
RT   associated with the emergence of human pathogenic strains.";
RL   Genome Biol. 8:R102.1-R102.16(2007).
RN   [3] {ECO:0000313|EMBL:AJI60776.1, ECO:0000313|Proteomes:UP000031872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U112 {ECO:0000313|EMBL:AJI60776.1,
RC   ECO:0000313|Proteomes:UP000031872};
RX   PubMed=25931589;
RA   Johnson S.L., Daligault H.E., Davenport K.W., Coyne S.R., Frey K.G.,
RA   Koroleva G.I., Broomall S.M., Bishop-Lilly K.A., Bruce D.C., Chertkov O.,
RA   Freitas T., Jaissle J., Ladner J.T., Rosenzweig C.N., Gibbons H.S.,
RA   Palacios G.F., Redden C.L., Xu Y., Minogue T.D., Chain P.S.;
RT   "Genome sequencing of 18 francisella strains to aid in assay development
RT   and testing.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2;
CC         Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000018,
CC         ECO:0000256|RuleBase:RU361171};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; CP000439; ABK90558.1; -; Genomic_DNA.
DR   EMBL; CP009633; AJI60776.1; -; Genomic_DNA.
DR   RefSeq; WP_003041366.1; NZ_CP009633.1.
DR   AlphaFoldDB; A0Q8J3; -.
DR   KEGG; ftn:FTN_1701; -.
DR   KEGG; ftx:AW25_287; -.
DR   BioCyc; FTUL401614:G1G75-1761-MONOMER; -.
DR   Proteomes; UP000000762; Chromosome.
DR   Proteomes; UP000031872; Chromosome.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF3; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382}.
FT   MOD_RES         266
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   448 AA;  50828 MW;  B5798B19FE0FA0D4 CRC64;
     MALHGKKDTI NNLDFFEQSL PKFKLPLNSQ DPLEVYQEIK DELMLDGNSK QNLATFCQTE
     VDDFIHKLMD DCIDKNMIDK DEYPQTAEIE SRCVNILANL WNSSAENAIG CSTTGSSEAA
     MLGGMAMKWR WRDKMKAQGK DYTKPNLVTG PVQVCWHKFA RYWDIELREI PMSNESLIMT
     PEAVLERCDE NTIGVVPTLG VTFTGQYEPV EQVCKALDDF ERQTGIDIPV HVDAASGGFL
     APFVEPELKW DFRLPRVKSI NSSGHKFGLS PLGVGWVIWA DKKYLPDDLI FNVNYLGGNM
     PTFALNFSRP GGQIVAQYYN FVRLGFEGYK KVHQLCYDVA EYIAKELRKM EIFEIIHAGE
     GGIPAVSWSL KATKEYSLFD ISEKVRAKGW QIAAYTMPTN REDLVVMRVL VRRGFSYDLA
     QLMIRDLVAV INSLEGKLKI LKRSSFAH
//