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Protein

RNA pyrophosphohydrolase

Gene

nudH

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciFTUL401614:G1G75-1605-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:nudHUniRule annotationImported
Synonyms:rppHUniRule annotation
Ordered Locus Names:FTN_1553Imported
OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000762 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiA0Q852

Structurei

3D structure databases

ProteinModelPortaliA0Q852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 148Nudix hydrolaseInterPro annotationAdd BLAST143

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxUniRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000066723
KOiK08311
OMAiRPCVGIM

Family and domain databases

CDDicd03671 Ap4A_hydrolase_plant_like, 1 hit
HAMAPiMF_00298 Nudix_RppH, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR022927 RppH
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

A0Q852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDKSGYRAN VAIVLLNKQN RVFWGQRRNR TSWQFPQGGV ATGETPLQAM
60 70 80 90 100
YRELHEEIGL RPQDVEVIAS TRDWYKYDIP DSLVRTKEPV CIGQKQKWFL
110 120 130 140 150
LKLKSPESYI DLDANDSPEF DNWRWVSYWY PINHVVYFKQ EVYRKALTYF

KEYI
Length:154
Mass (Da):18,476
Last modified:January 9, 2007 - v1
Checksum:iBF8A0D08A81096B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA Translation: ABK90417.1
RefSeqiWP_003037539.1, NZ_CP009633.1

Genome annotation databases

EnsemblBacteriaiABK90417; ABK90417; FTN_1553
KEGGiftn:FTN_1553
ftx:AW25_445

Similar proteinsi

Entry informationi

Entry nameiA0Q852_FRATN
AccessioniPrimary (citable) accession number: A0Q852
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health