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A0Q7X9

- LPXB_FRATN

UniProt

A0Q7X9 - LPXB_FRATN

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciFNOV401614:GC4M-1476-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:FTN_1477
    OrganismiFrancisella tularensis subsp. novicida (strain U112)
    Taxonomic identifieri401614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000762: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Lipid-A-disaccharide synthasePRO_1000049397Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi401614.FTN_1477.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q7X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0Q7X9-1 [UniParc]FASTAAdd to Basket

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    MRIGIVAGEL SGDQLGGTLV EALKQKYPNA IIEGIGGPKM AAAGFKSLYP    50
    MDALSLIGFL EIISKGLRIL SIRRKIINYF KQNKPDIFIG IDAPDFNLTV 100
    EKELRSVGIK TIHYVSPKIW VWREYRIKKI RKATDKILAI LPFETEYYKN 150
    RHKFEAIYVG HPLAKNIPIH IDRTKYRDKL GLKGNSLPIL SVLPGSRTTE 200
    VSRLLPLFLL ALQKLVDAGY KFKAIMPLAK PSLKPLFAKY KEQIDSLGIE 250
    VFETNSHDVL KASDLSLLAS GTATLEAMLC KLPMVVGYKL SWLSALIGRM 300
    LIGNHSYWAF PNILHKSEII KELIQEDCTV DNLFSELKRL FDDKQRNDYI 350
    VEEFEKIHKE MVIDTESKII QVLNTMIEKS 380
    Length:380
    Mass (Da):43,117
    Last modified:January 9, 2007 - v1
    Checksum:iD1CF476843C10ED4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK90344.1.
    RefSeqiWP_003040462.1. NC_008601.1.
    YP_899098.1. NC_008601.1.

    Genome annotation databases

    EnsemblBacteriaiABK90344; ABK90344; FTN_1477.
    GeneIDi4548572.
    KEGGiftn:FTN_1477.
    PATRICi17936117. VBIFraNov128299_1509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK90344.1 .
    RefSeqi WP_003040462.1. NC_008601.1.
    YP_899098.1. NC_008601.1.

    3D structure databases

    ProteinModelPortali A0Q7X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 401614.FTN_1477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK90344 ; ABK90344 ; FTN_1477 .
    GeneIDi 4548572.
    KEGGi ftn:FTN_1477.
    PATRICi 17936117. VBIFraNov128299_1509.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci FNOV401614:GC4M-1476-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U112.

    Entry informationi

    Entry nameiLPXB_FRATN
    AccessioniPrimary (citable) accession number: A0Q7X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3