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A0Q7T7

- A0Q7T7_FRATN

UniProt

A0Q7T7 - A0Q7T7_FRATN

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei253 – 2531Critical for catalysisUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFNOV401614:GC4M-1433-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Name:icdImported
Ordered Locus Names:FTN_1434Imported
OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000762: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi401614.FTN_1434.

Structurei

3D structure databases

ProteinModelPortaliA0Q7T7.
SMRiA0Q7T7. Positions 3-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q7T7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLSARILANF
60 70 80 90 100
NDYLTAEQKC SDDLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS
110 120 130 140 150
KGYKIPDYPY EPKDDKEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK
160 170 180 190 200
KYAEKHPHSM GEWTKDSKSH VASMSADDFY ANEKSYIVPK ATKVKIVHTD
210 220 230 240 250
TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKNEIAK AKKEGTLLSL
260 270 280 290 300
HLKATMMKVS DPILFGHAVE IFFEDIFKKY AKEFKELCVN PRNGWGDAVE
310 320 330 340 350
KIKQLPQELQ DKINADIEKV FAKQPDIAMV NSDKGITNLN VPSDVIIDAS
360 370 380 390 400
MPAAIRSSGK MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA
410 420 430 440 450
TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDAEG NVIFEHQVEK
460 470 480 490 500
GDIWRACQTK DIAVKDWVKL AVNRAKITQN PAIFWLDSKR AHDRNLIAKV
510 520 530 540 550
NEYLTHHDTT GLDIQILSPV EATKYSLKRM KEGKNTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD
610 620 630 640 650
SLGEFLALGA SLEDLAIKTR DAKIKVLAET LSQANKDFLD NDKSPRRKVG
660 670 680 690 700
ELDTRGSHFY LAYYWVKALA EQTGNAELKA KFEPIYIELK ANKDKIVKEL
710 720 730
NDAQGKKVDV GGYYHMDRVK LDAVMRPSKT FNTILAQI
Length:738
Mass (Da):82,260
Last modified:January 9, 2007 - v1
Checksum:iFE75E8AF37698124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA. Translation: ABK90302.1.
RefSeqiWP_011733711.1. NC_008601.1.
YP_899056.1. NC_008601.1.

Genome annotation databases

EnsemblBacteriaiABK90302; ABK90302; FTN_1434.
GeneIDi4548360.
KEGGiftn:FTN_1434.
PATRICi17936031. VBIFraNov128299_1467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA. Translation: ABK90302.1 .
RefSeqi WP_011733711.1. NC_008601.1.
YP_899056.1. NC_008601.1.

3D structure databases

ProteinModelPortali A0Q7T7.
SMRi A0Q7T7. Positions 3-738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 401614.FTN_1434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK90302 ; ABK90302 ; FTN_1434 .
GeneIDi 4548360.
KEGGi ftn:FTN_1434.
PATRICi 17936031. VBIFraNov128299_1467.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci FNOV401614:GC4M-1433-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: U112Imported.

Entry informationi

Entry nameiA0Q7T7_FRATN
AccessioniPrimary (citable) accession number: A0Q7T7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3