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A0Q7T7

- A0Q7T7_FRATN

UniProt

A0Q7T7 - A0Q7T7_FRATN

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei253 – 2531Critical for catalysisUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganese
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei545 – 5451SubstrateUniRule annotation
    Metal bindingi546 – 5461Magnesium or manganese
    Metal bindingi550 – 5501Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciFNOV401614:GC4M-1433-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported
    Gene namesi
    Name:icdImported
    Ordered Locus Names:FTN_1434Imported
    OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
    Taxonomic identifieri401614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000762: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi401614.FTN_1434.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q7T7.
    SMRiA0Q7T7. Positions 3-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0Q7T7-1 [UniParc]FASTAAdd to Basket

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    MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLSARILANF    50
    NDYLTAEQKC SDDLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS 100
    KGYKIPDYPY EPKDDKEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK 150
    KYAEKHPHSM GEWTKDSKSH VASMSADDFY ANEKSYIVPK ATKVKIVHTD 200
    TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKNEIAK AKKEGTLLSL 250
    HLKATMMKVS DPILFGHAVE IFFEDIFKKY AKEFKELCVN PRNGWGDAVE 300
    KIKQLPQELQ DKINADIEKV FAKQPDIAMV NSDKGITNLN VPSDVIIDAS 350
    MPAAIRSSGK MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA 400
    TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDAEG NVIFEHQVEK 450
    GDIWRACQTK DIAVKDWVKL AVNRAKITQN PAIFWLDSKR AHDRNLIAKV 500
    NEYLTHHDTT GLDIQILSPV EATKYSLKRM KEGKNTISVT GNVLRDYLTD 550
    LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD 600
    SLGEFLALGA SLEDLAIKTR DAKIKVLAET LSQANKDFLD NDKSPRRKVG 650
    ELDTRGSHFY LAYYWVKALA EQTGNAELKA KFEPIYIELK ANKDKIVKEL 700
    NDAQGKKVDV GGYYHMDRVK LDAVMRPSKT FNTILAQI 738
    Length:738
    Mass (Da):82,260
    Last modified:January 9, 2007 - v1
    Checksum:iFE75E8AF37698124
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK90302.1.
    RefSeqiYP_899056.1. NC_008601.1.

    Genome annotation databases

    EnsemblBacteriaiABK90302; ABK90302; FTN_1434.
    GeneIDi4548360.
    KEGGiftn:FTN_1434.
    PATRICi17936031. VBIFraNov128299_1467.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK90302.1 .
    RefSeqi YP_899056.1. NC_008601.1.

    3D structure databases

    ProteinModelPortali A0Q7T7.
    SMRi A0Q7T7. Positions 3-738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 401614.FTN_1434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK90302 ; ABK90302 ; FTN_1434 .
    GeneIDi 4548360.
    KEGGi ftn:FTN_1434.
    PATRICi 17936031. VBIFraNov128299_1467.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci FNOV401614:GC4M-1433-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U112Imported.

    Entry informationi

    Entry nameiA0Q7T7_FRATN
    AccessioniPrimary (citable) accession number: A0Q7T7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3